Preview

Epilepsy and paroxysmal conditions

Advanced search

CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES

https://doi.org/10.17749/2077-8333.2017.9.1.069-078

Full Text:

Abstract

Childhood absence  epilepsy  (CAE) is an idiopathic generalized epilepsy,  which could be attributed to genetic  forms according to the latest proposals  of the Commission  on Classification and Terminology of the International  League Against  Epilepsy  (2016).  CAE has  specific  clinical and  encephalographic  characteristics.  Data regarding cognitive impairment  in children with CAE is still controversial. There are some  attempts  to introduce more  strict diagnostic criteria to be able to define the disease course and prognosis of this form of epilepsy. These are the criteria proposed by Panayiotopoulos C. P.  in  2005. 

Objective.  To  asses   specific  features  of  CAE taking  into  account  the  criteria of Panayiotopoulos C. P. (2005).

Materials  and  methods. We have retrospectively  analyzed 186 cases  of CAE in children; study participants were divided into groups according to Panayiotopoulos’s criteria (2005).

Results.  Children from the group allocated in accordance with Panayiotopoulos’s criteria had neither generalized tonic-clonic seizures (GTCS) nor myoclonic  seizures; control of absence  seizures  was achieved in 94.3% of the cases; almost  90% of children in this group received monotherapy with mean treatment duration of 2.8 years.

Conclusions. The use of more precise diagnostic criteria for CAE will help to predict clinical course of this form of epilepsy and its outcome.

About the Authors

I. O. Schederkina
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Schederkina Inna Olegovna – MD, head of the Center for treatment of cerebrovascular pathology in children and adolescents at Morozov ChCH; Associate professor  at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.

4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997



A. A. Shadrova
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Shadrova Anna Alekseevna – neurologist at Morozov ChCH; Assistant professor  at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.

4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997



N. N. Zavadenko
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Zavadenko Nikolay Nikolaevich – MD, PhD, Professor,  Head of the Department  of Neurology, Neurosurgery  and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.

1 Ostrovityanova St., Moscow, 117997, Tel.: +7(495)9369452



I. E. Koltunov
Morozov Children’s Clinical Hospital; Peoples’ Friendship University of Russia
Russian Federation

Koltunov Igor’ Efimovich – MD, PhD, Professor,  honored doctor of the Russian Federation, chief doctor of Morozov ChCH; Chief pediatrician of Moscow Department of Healthcare, head of the Department of Evidence-based Medicine at PFUR.

4 Dobrininsky per., 1/9, Moscow, 119037; 10/3 Miklukho-Maklaya St., Moscow,  117198, Tel.: +7(495)9598800



References

1. Karlov V. A. Epilepsy in children and adults, women and children [Epilepsiya u detei i vzroslykh, zhenshchin i detei (in Russian)]. Moscow. 2010; 718 p.

2. Pediatric epileptology: a Guide for physicians. Ed. by A. S. Petrukhin [Epileptologiya detskogo vozrasta: Rukovodstvo dlya vrachei. Pod red A. S. Petrukhina (in Russian)]. Moscow. 2000; 624 p.

3. Classification of epilepsies: New concepts for discussion and debate – special report of the ILAE Classification Task Force of the Comission for Classification and Terminology I. Epilepsia. 2016; 1-8.

4. Duron R. M., Medina M. T., Martinez O. J. et al. Seizures of idiopathic generelazed epilepsies. Epilepsia. 2005; 46 (9): 34-47.

5. Loiseau P., Panayiotopoulos CP. Childhood absence epilepsy. In Gilman S, ed. Medlink Neurilogy, San Diego SA:Arbor Publishing Corp, 2004.

6. Loiseau P., Panayiotopoulos C. P., Hirsh E. Childhood absence epilepsy and related syndromes. In Roger J., Bureau M., Dravet C., Genton P., Tassinari C. A., Wolf P. eds. Epileptic syndromes in infancy, childhood and adolesecence (3rd edn). 2002; 285-304.

7. Olsson I., Hagberg G. Epidemiology of absence epilepsy. III Clinical aspects. Acta Paediatr Scand. 1991; 80: 1066-72.

8. Wirrell E. C. Natural history absence epilepsy in children. Can J Neurol Sci. 2003; 30: 184-8.

9. Asadi-Pooya A.A., Emami M., Nikseresht A. Early-onset versus typical childhood absence epilepsy; clinical and electrographic characteristics. Seizure. 2012 May; 21 (4): 273-5.

10. Covanis A., Skiadas K., Loli N., Lada C., Theodorou V. Absence epilepsy: early prognostic signs. Seizure. 1992 Dec; 1 (4): 281-9.

11. Gibbs F., Davis A., Lennox W. Petit mal. Arch Neurol Psychiatr. 1935; 34: 1133-48.

12. Loiseau P., Duche B., Pedespan J. M. Absence epilepsies. Epilepsia. 1995; 36: 1182-6.

13. Panayiotopoulos C. P. Idiopathic generalised epilepsies: a review and modern approach. Epilepsia. 2005; 1: 241-152.

14. Dieterich E., Doose H., Baier W. K., Fichsel H. Longterm follow-up of childhood epilepsy with absence.II. Absence-epilepsy with initial grand mal. Neuropediatrics. 1985; 16: 155-8.

15. Marini C., Harkin L. A., Wallace R. H., Mulley J. C., Scheffer I. E., Bercovich S. F. Childhood absence epilepsy and febrile seizures: a family with a GABA(A) receptor mutation. Brain. 2003; 126: 230-40.

16. Gupta A. Absence epilepsy in childhood. Epilepsy Curr. 2016 May; 16 (3): 145-146.

17. Masur D., Shinnar S., Cnaan A. et al. Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy. Neurology. 2013 Oct 29; 81 (18): 1572-80.

18. Glauser T. A., Cnaan A., Shinnar S. et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 4; 362 (9): 790-9.

19. Shinnar S., Cnaan A., Hu F., Clark P. et al. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology. 2015; 85: 1108-1114.

20. Cerminara C. et al. Attention impairment in childhood absence epilepsy: an impulsivity problem? Epilepsy and behavior. 2013; 27 (2): 124-27.

21. Caplan R. et al. Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities. Epilepsy Curr. 2009 Jul-Aug; 9 (4): 104-7.

22. Dieterich E., Baier W. K., Doose H., Tuxhorn I., Fichsel H. Longterm follow-up of childhood epilepsy with absence. I. Epilepsy with absence at onset. Neuropediatrics. 1985; 16: 149-54.

23. Wirrell E. C., Camfield C. S., Camfield P. R., Gordon K. E., Dooley J. M. Long-term prognosis of typical childhood absence epilepsy: remission or progression to juvenile myoclonic epilepsy. Neurology. 1996; 47: 912-8.

24. Trinka E., Baumgartner S., Unterberger I., Unterrainer J., Luef G., Haberlandt E. et al. Long-term prognosis for childhood and juvenile absence epilepsy. J Neurol. 2004; 251: 1235-41.

25. Kent G. P., Schefft B. K., Howe S. R., Szaflarski J. P. et al. The effects of duration of intractable epilepsy on memory function. Epilepsy Behav. 2006 Nov; 9 (3): 469-77.

26. Mariani E. et al. Interictal paroxysmal EEG abnormalities in childhood absence epilepsy. Seizures. May 2011; 20 (4): 299-304.

27. Jocić-Jakubi B., Jovanović M., Janković D. S., Lagae L. Frontal-onset absences in children: associated with worse outcome? A replication study. Seizure. 2009 May; 18 (4): 275-8.

28. Caplan R. et al. Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities. Epilepsy Curr. 2009 Jul-Aug; 9 (4): 104-7.

29. Holmes M. D., Brown M., Tucker D. M. Are “generalized” seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence. Epilepsia. 2004 Dec; 45 (12): 1568-79.

30. Alvarez J. A., Emory E. Executive function and the frontal lobes: a meta-analytic review. Neuropsychol Rev. 2006 Mar; 16 (1): 17-42.


For citation:


Schederkina I.O., Shadrova A.A., Zavadenko N.N., Koltunov I.E. CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES. Epilepsy and paroxysmal conditions. 2017;9(1):69-78. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.1.069-078

Views: 250


ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)