CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES
https://doi.org/10.17749/2077-8333.2017.9.1.069-078
Abstract
Childhood absence epilepsy (CAE) is an idiopathic generalized epilepsy, which could be attributed to genetic forms according to the latest proposals of the Commission on Classification and Terminology of the International League Against Epilepsy (2016). CAE has specific clinical and encephalographic characteristics. Data regarding cognitive impairment in children with CAE is still controversial. There are some attempts to introduce more strict diagnostic criteria to be able to define the disease course and prognosis of this form of epilepsy. These are the criteria proposed by Panayiotopoulos C. P. in 2005.
Objective. To asses specific features of CAE taking into account the criteria of Panayiotopoulos C. P. (2005).
Materials and methods. We have retrospectively analyzed 186 cases of CAE in children; study participants were divided into groups according to Panayiotopoulos’s criteria (2005).
Results. Children from the group allocated in accordance with Panayiotopoulos’s criteria had neither generalized tonic-clonic seizures (GTCS) nor myoclonic seizures; control of absence seizures was achieved in 94.3% of the cases; almost 90% of children in this group received monotherapy with mean treatment duration of 2.8 years.
Conclusions. The use of more precise diagnostic criteria for CAE will help to predict clinical course of this form of epilepsy and its outcome.About the Authors
I. O. Schederkina
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Schederkina Inna Olegovna – MD, head of the Center for treatment of cerebrovascular pathology in children and adolescents at Morozov ChCH; Associate professor at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.
4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997
A. A. Shadrova
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Shadrova Anna Alekseevna – neurologist at Morozov ChCH; Assistant professor at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.
4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997
N. N. Zavadenko
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Zavadenko Nikolay Nikolaevich – MD, PhD, Professor, Head of the Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.
1 Ostrovityanova St., Moscow, 117997, Tel.: +7(495)9369452
I. E. Koltunov
Morozov Children’s Clinical Hospital; Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Koltunov Igor’ Efimovich – MD, PhD, Professor, honored doctor of the Russian Federation, chief doctor of Morozov ChCH; Chief pediatrician of Moscow Department of Healthcare, head of the Department of Evidence-based Medicine at PFUR.
4 Dobrininsky per., 1/9, Moscow, 119037; 10/3 Miklukho-Maklaya St., Moscow, 117198, Tel.: +7(495)9598800
References
1. Karlov V. A. Epilepsy in children and adults, women and children [Epilepsiya u detei i vzroslykh, zhenshchin i detei (in Russian)]. Moscow. 2010; 718 p.
2. Pediatric epileptology: a Guide for physicians. Ed. by A. S. Petrukhin [Epileptologiya detskogo vozrasta: Rukovodstvo dlya vrachei. Pod red A. S. Petrukhina (in Russian)]. Moscow. 2000; 624 p.
3. Classification of epilepsies: New concepts for discussion and debate – special report of the ILAE Classification Task Force of the Comission for Classification and Terminology I. Epilepsia. 2016; 1-8.
4. Duron R. M., Medina M. T., Martinez O. J. et al. Seizures of idiopathic generelazed epilepsies. Epilepsia. 2005; 46 (9): 34-47.
5. Loiseau P., Panayiotopoulos CP. Childhood absence epilepsy. In Gilman S, ed. Medlink Neurilogy, San Diego SA:Arbor Publishing Corp, 2004.
6. Loiseau P., Panayiotopoulos C. P., Hirsh E. Childhood absence epilepsy and related syndromes. In Roger J., Bureau M., Dravet C., Genton P., Tassinari C. A., Wolf P. eds. Epileptic syndromes in infancy, childhood and adolesecence (3rd edn). 2002; 285-304.
7. Olsson I., Hagberg G. Epidemiology of absence epilepsy. III Clinical aspects. Acta Paediatr Scand. 1991; 80: 1066-72.
8. Wirrell E. C. Natural history absence epilepsy in children. Can J Neurol Sci. 2003; 30: 184-8.
9. Asadi-Pooya A.A., Emami M., Nikseresht A. Early-onset versus typical childhood absence epilepsy; clinical and electrographic characteristics. Seizure. 2012 May; 21 (4): 273-5.
10. Covanis A., Skiadas K., Loli N., Lada C., Theodorou V. Absence epilepsy: early prognostic signs. Seizure. 1992 Dec; 1 (4): 281-9.
11. Gibbs F., Davis A., Lennox W. Petit mal. Arch Neurol Psychiatr. 1935; 34: 1133-48.
12. Loiseau P., Duche B., Pedespan J. M. Absence epilepsies. Epilepsia. 1995; 36: 1182-6.
13. Panayiotopoulos C. P. Idiopathic generalised epilepsies: a review and modern approach. Epilepsia. 2005; 1: 241-152.
14. Dieterich E., Doose H., Baier W. K., Fichsel H. Longterm follow-up of childhood epilepsy with absence.II. Absence-epilepsy with initial grand mal. Neuropediatrics. 1985; 16: 155-8.
15. Marini C., Harkin L. A., Wallace R. H., Mulley J. C., Scheffer I. E., Bercovich S. F. Childhood absence epilepsy and febrile seizures: a family with a GABA(A) receptor mutation. Brain. 2003; 126: 230-40.
16. Gupta A. Absence epilepsy in childhood. Epilepsy Curr. 2016 May; 16 (3): 145-146.
17. Masur D., Shinnar S., Cnaan A. et al. Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy. Neurology. 2013 Oct 29; 81 (18): 1572-80.
18. Glauser T. A., Cnaan A., Shinnar S. et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 4; 362 (9): 790-9.
19. Shinnar S., Cnaan A., Hu F., Clark P. et al. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology. 2015; 85: 1108-1114.
20. Cerminara C. et al. Attention impairment in childhood absence epilepsy: an impulsivity problem? Epilepsy and behavior. 2013; 27 (2): 124-27.
21. Caplan R. et al. Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities. Epilepsy Curr. 2009 Jul-Aug; 9 (4): 104-7.
22. Dieterich E., Baier W. K., Doose H., Tuxhorn I., Fichsel H. Longterm follow-up of childhood epilepsy with absence. I. Epilepsy with absence at onset. Neuropediatrics. 1985; 16: 149-54.
23. Wirrell E. C., Camfield C. S., Camfield P. R., Gordon K. E., Dooley J. M. Long-term prognosis of typical childhood absence epilepsy: remission or progression to juvenile myoclonic epilepsy. Neurology. 1996; 47: 912-8.
24. Trinka E., Baumgartner S., Unterberger I., Unterrainer J., Luef G., Haberlandt E. et al. Long-term prognosis for childhood and juvenile absence epilepsy. J Neurol. 2004; 251: 1235-41.
25. Kent G. P., Schefft B. K., Howe S. R., Szaflarski J. P. et al. The effects of duration of intractable epilepsy on memory function. Epilepsy Behav. 2006 Nov; 9 (3): 469-77.
26. Mariani E. et al. Interictal paroxysmal EEG abnormalities in childhood absence epilepsy. Seizures. May 2011; 20 (4): 299-304.
27. Jocić-Jakubi B., Jovanović M., Janković D. S., Lagae L. Frontal-onset absences in children: associated with worse outcome? A replication study. Seizure. 2009 May; 18 (4): 275-8.
28. Caplan R. et al. Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities. Epilepsy Curr. 2009 Jul-Aug; 9 (4): 104-7.
29. Holmes M. D., Brown M., Tucker D. M. Are “generalized” seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence. Epilepsia. 2004 Dec; 45 (12): 1568-79.
30. Alvarez J. A., Emory E. Executive function and the frontal lobes: a meta-analytic review. Neuropsychol Rev. 2006 Mar; 16 (1): 17-42.
Review
For citations:
Schederkina I.O., Shadrova A.A., Zavadenko N.N., Koltunov I.E. CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES. Epilepsy and paroxysmal conditions. 2017;9(1):69-78. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.1.069-078
Views:
1094
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
