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CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES

https://doi.org/10.17749/2077-8333.2017.9.1.069-078

Abstract

Childhood absence  epilepsy  (CAE) is an idiopathic generalized epilepsy,  which could be attributed to genetic  forms according to the latest proposals  of the Commission  on Classification and Terminology of the International  League Against  Epilepsy  (2016).  CAE has  specific  clinical and  encephalographic  characteristics.  Data regarding cognitive impairment  in children with CAE is still controversial. There are some  attempts  to introduce more  strict diagnostic criteria to be able to define the disease course and prognosis of this form of epilepsy. These are the criteria proposed by Panayiotopoulos C. P.  in  2005. 

Objective.  To  asses   specific  features  of  CAE taking  into  account  the  criteria of Panayiotopoulos C. P. (2005).

Materials  and  methods. We have retrospectively  analyzed 186 cases  of CAE in children; study participants were divided into groups according to Panayiotopoulos’s criteria (2005).

Results.  Children from the group allocated in accordance with Panayiotopoulos’s criteria had neither generalized tonic-clonic seizures (GTCS) nor myoclonic  seizures; control of absence  seizures  was achieved in 94.3% of the cases; almost  90% of children in this group received monotherapy with mean treatment duration of 2.8 years.

Conclusions. The use of more precise diagnostic criteria for CAE will help to predict clinical course of this form of epilepsy and its outcome.

About the Authors

I. O. Schederkina
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Schederkina Inna Olegovna – MD, head of the Center for treatment of cerebrovascular pathology in children and adolescents at Morozov ChCH; Associate professor  at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.

4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997



A. A. Shadrova
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Shadrova Anna Alekseevna – neurologist at Morozov ChCH; Assistant professor  at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.

4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997



N. N. Zavadenko
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Zavadenko Nikolay Nikolaevich – MD, PhD, Professor,  Head of the Department  of Neurology, Neurosurgery  and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.

1 Ostrovityanova St., Moscow, 117997, Tel.: +7(495)9369452



I. E. Koltunov
Morozov Children’s Clinical Hospital; Peoples’ Friendship University of Russia
Russian Federation

Koltunov Igor’ Efimovich – MD, PhD, Professor,  honored doctor of the Russian Federation, chief doctor of Morozov ChCH; Chief pediatrician of Moscow Department of Healthcare, head of the Department of Evidence-based Medicine at PFUR.

4 Dobrininsky per., 1/9, Moscow, 119037; 10/3 Miklukho-Maklaya St., Moscow,  117198, Tel.: +7(495)9598800



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Review

For citations:


Schederkina I.O., Shadrova A.A., Zavadenko N.N., Koltunov I.E. CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES. Epilepsy and paroxysmal conditions. 2017;9(1):69-78. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.1.069-078

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)