CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES
https://doi.org/10.17749/2077-8333.2017.9.1.069-078
Abstract
Childhood absence epilepsy (CAE) is an idiopathic generalized epilepsy, which could be attributed to genetic forms according to the latest proposals of the Commission on Classification and Terminology of the International League Against Epilepsy (2016). CAE has specific clinical and encephalographic characteristics. Data regarding cognitive impairment in children with CAE is still controversial. There are some attempts to introduce more strict diagnostic criteria to be able to define the disease course and prognosis of this form of epilepsy. These are the criteria proposed by Panayiotopoulos C. P. in 2005.
Objective. To asses specific features of CAE taking into account the criteria of Panayiotopoulos C. P. (2005).
Materials and methods. We have retrospectively analyzed 186 cases of CAE in children; study participants were divided into groups according to Panayiotopoulos’s criteria (2005).
Results. Children from the group allocated in accordance with Panayiotopoulos’s criteria had neither generalized tonic-clonic seizures (GTCS) nor myoclonic seizures; control of absence seizures was achieved in 94.3% of the cases; almost 90% of children in this group received monotherapy with mean treatment duration of 2.8 years.
Conclusions. The use of more precise diagnostic criteria for CAE will help to predict clinical course of this form of epilepsy and its outcome.About the Authors
I. O. Schederkina
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Schederkina Inna Olegovna – MD, head of the Center for treatment of cerebrovascular pathology in children and adolescents at Morozov ChCH; Associate professor at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.
4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997
A. A. Shadrova
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Shadrova Anna Alekseevna – neurologist at Morozov ChCH; Assistant professor at Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.
4 Dobrininsky per., 1/9, Moscow, 119037; 1 Ostrovityanova St., Moscow, 117997
N. N. Zavadenko
Morozov Children’s Clinical Hospital; N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Zavadenko Nikolay Nikolaevich – MD, PhD, Professor, Head of the Department of Neurology, Neurosurgery and Medical Genetics, pediatric faculty of N. I. Pirogov RNRMU.
1 Ostrovityanova St., Moscow, 117997, Tel.: +7(495)9369452
I. E. Koltunov
Morozov Children’s Clinical Hospital; Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Koltunov Igor’ Efimovich – MD, PhD, Professor, honored doctor of the Russian Federation, chief doctor of Morozov ChCH; Chief pediatrician of Moscow Department of Healthcare, head of the Department of Evidence-based Medicine at PFUR.
4 Dobrininsky per., 1/9, Moscow, 119037; 10/3 Miklukho-Maklaya St., Moscow, 117198, Tel.: +7(495)9598800
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Review
For citations:
Schederkina I.O., Shadrova A.A., Zavadenko N.N., Koltunov I.E. CHILDHOOD ABSENCE EPILEPSY: SPECIFIC FEATURES OF THE DISEASE COURSE AND OUTCOMES. Epilepsy and paroxysmal conditions. 2017;9(1):69-78. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.1.069-078
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