MONITORING OF SIDE EFFECTS OF THE ANTIEPILEPTIC DRUGS ON REPRODUCTIVE HEALTH IN WOMEN WITH EPILEPSY

G. V. Odintsova; N. Y. Koroleva; A. A. Chugunova; L. A. Saykova

MONITORING OF SIDE EFFECTS OF THE ANTIEPILEPTIC DRUGS ON REPRODUCTIVE HEALTH IN WOMEN WITH EPILEPSY

G. V. Odintsova, N. Y. Koroleva, A. A. Chugunova, L. A. Saykova

Full Text:

Abstract

Abstract: there are two main trends: gender aspects and reproductive problems in women with epilepsy. The second trend is relatively new and is associated with exposure to antiepileptic drugs, seizures in the hormonal status and reproductive functions. In international clinical trials of new antiepileptic drugs to study their adverse events on the reproductive system is still not compulsory. A prospective observational single-center uncontrolled study of antiepileptic drugs side effects on reproductive health of women with epilepsy performed. One hundred fifty five women with epilepsy in reproductive age were included in the study. Clinical diagnostic screening’s complex was developed and tested to diagnose of endocrine reproductive disorders in women with antiepileptic therapy of epilepsy. In conclusion, the primary assessment of the reproductive health status in epilepsy should conduct on the neurological visits. Safety of antiepileptic drug treatment should include of reproductive health monitoring consisting in the collection of gynecological anamnesis and clinical examination.

Keywords

female epilepsy, reproductive health, antiepileptic therapy, monitoring of safety,

About the Authors

G. V. Odintsova

Institute of Human Brain n.a. N.P. Bekhtereva of RAS, St. Petersburg
Russian Federation

N. Y. Koroleva

Institute of Human Brain n.a. N.P. Bekhtereva of RAS, St. Petersburg
Russian Federation

A. A. Chugunova

Institute of Human Brain n.a. N.P. Bekhtereva of RAS, St. Petersburg
Russian Federation

L. A. Saykova

Northwestern State Medical University n.a. I.I. Mechnikov of Ministry of Ministry of Health of the Russian Federation, St. Petersburg
Russian Federation

References

1. Blinov D.V., Dizhevskaja E.V. Akusherstvo, ginekologija i reprodukcija. 2011; 3: 45-51.

2. Blinov D.V. Akusherstvo, ginekologija i reprodukcija. 2011; 4: 44-47.

3. Vlasov P.N. Zhurn. nevropatologii i psihiatrii im. S.S. Korsakova. 2006; 1: 47-52.

4. Vlasov P.N. Jepilepsija i paroksizmal’nye sostojanija. 2011; 4: 45-46.

5. Vlasov P.N. Jepilepsija i paroksizmal’nye sostojanija. 2009; 1: 8-13.

6. Gynecology from puberty to menopause. ed. by Je.K. Ajlamazjan [Ginekologija ot pubertata do menopauzy. Pod red. Je.K. Ajlamazjana]. Moscow. 2006; 496 s.

7. Goranskij Ju.I. Zdorov’e Ukrainy. 2007; 23 (1:12): 58-59.

8. Diagnostika, lechenie, social’nye aspekty jepilepsii. Materialy satellitnogo simpoziuma 7-go evropejskogo kongressa po jepilepsii. Pod red. Guseva E.I., Geht A.B. (Diagnosis, treatment, social aspects of epilepsy. Satellite Symposium Proceedings of the 7th European Congress on Epilepsy. ed. by Guseva E.I., Geht A.B. SPb.). 2006. 241 s.

9. Dizhevskaja E.V., Blinov D.V. Akusherstvo, ginekologija i reprodukcija. 2011; 3: 35-44.

10. Zheleznova E.V. Zhurn. nevrologii i psihiatrii im. S.S. Korsakova. 2005;105 (2): 59-64.

11. Zheleznova E.V., Sokolova L.V., Zemljanaja A.A. Sovremennye problemy psihiatricheskoj jendokrinologii. Moscow. 2004; 196.

12. Zenkov L.R. Rossijskij medicinskij zhurnal. 2005; 5: 41-46.

13. Clinical endokrinoloriya: manual (3rd edition.). ed. by N.T. Starkovoj [Klinicheskaja jendokri-nolorija: rukovodstvo (3 e izd.). Pod red. N.T. Starkovoj]. St. Petersburg. 2002; 576 s.

14. Makarov I.O., Ovsjannikova T.V., Shemanaeva T.V., Kulikov I.A., Guriev T.D. Akusherstvo, ginekologija i reprodukcija. 2013; 2: 20-22.

15. Makarov I.O., Ovsjannikova T.V., Shemanaeva T.V., Borovkova E.I., Kulikov I.A., Guriev T.D. Akusherstvo, ginekologija i reprodukcija. 2013; 2: 23-26.

16. Muhin K.Ju., Petruhin A.S., Rykova E.A. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 1997; 7: 25-31.

17. Odincova G.V., Koroleva N.Ju., Chugunova A.A., Sajkova L.A. Jepilepsija i paroksizmal’nye sostojanija. 2011; 3: 29-32.

18. Pylaeva O.A., Voronkova K.V., Petruhin A.S. Farmateka. 2004; 9-10:87: 33-41.

19. Guidelines for outpatient care in obstetrics and gynecology. ed. by V.I. Kulakov, V.N. Prilepskaya, V.E. Radzinskiy [Rukovodstvo po ambulatorno-poliklinicheskoj pomoshhi v akusherstve i ginekologii. Pod red. V.I. Kulakova, V.N. Prilepskoj, V.E. Radzinskogo]. Moscow. 2006. 1056 s.

20. Serov V.N., Prilepskaja V.N., Ovsjannikova T.V. Gynecological endocrinology. Moscow. 2004. 520 s.

21. Sidorova I.S., Unanjan A.L., Ageev M.B., Vedernikova N.V., Zholobova M.N. Akusherstvo, ginekologija i reprodukcija. 2012; 4: 22-28.

22. Bauer J.T. Isojдrvi J.I. Herzog A.G. Reuber M. et al. Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management. J. Neurol. Neurosurg. Psychiatry. 2002; 73: 121-125.

23. Galimberti C., Magri F et al. Changes in sex steroid levels in women with epilepsy on treatment: Relationship with antiepileptic trerapies and seizure frequency. Epilepsia. 2009; 50: 28-32.

24. Herzog A.G. Menstrual disorders in women with epilepsy. Neurology. Mar 28, 2006; 66 (3): 23-8.

Supplementary files

For citation: Odintsova G.V., Koroleva N.Y., Chugunova A.A., Saykova L.A. MONITORING OF SIDE EFFECTS OF THE ANTIEPILEPTIC DRUGS ON REPRODUCTIVE HEALTH IN WOMEN WITH EPILEPSY. Epilepsia and paroxyzmal conditions. 2014;6(2):12-18.

Refbacks

There are currently no refbacks.

ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)

Username
Password