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Epilepsia and paroxyzmal conditions

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Duration of epilepsy and severity of the disease in neurosurgical patients

https://doi.org/10.17749/2077-8333.2018.10.3.044-051

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Abstract

The problem of a late referral to surgical treatment in epilepsy was addressed in this study.

Objective: To elucidate whether the course of epilepsy is influenced by the duration of the disease.

Materials and Methods. A cohort of 91 patients with epilepsy who underwent surgical interventions from 2012 to 2017, were retrospectively studied. The disease dynamics (frequency and type of seizures) as well as the EEG changes were assessed.

Results. Of those patients, 77% had epilepsy more than 10 years, and 41% – more than 20 years. The temporal localization was found in 71% of cases, and the extra-temporal – in 29%. In all patients, seizures occurred at least once a month. Secondary generalized seizures were found in 58% of patients, and status epilepticus was observed in 30% of cases.

Conclusion. The course of epilepsy in the clinical and neurophysiological terms deteriorates with a long duration of the disease. The present results can be used to determine the optimal time for a referral for surgical treatment.

About the Authors

G. V. Odintsova
Russian Polenov Neurosurgical Institute – a branch of North-Western Federal Medical Research Center n. a. V.A. Almazov
Russian Federation

Odintsova Galina Vyacheslavovna – MD, PhD, Neurologist, Senior Researcher at the Department of Pediatric Neurosurgery.

Mayakovskogo Str., St Petersburg 191014



M. V. Aleksandrov
Russian Polenov Neurosurgical Institute – a branch of North-Western Federal Medical Research Center n. a. V.A. Almazov
Russian Federation

Aleksandrov Mikhail Vsevolodovich – MD, PhD, Professor & Head, Department of Clinical Neurophysiology.

Mayakovskogo Str., St Petersburg 191014



A. Yu. Ulitin
Russian Polenov Neurosurgical Institute – a branch of North-Western Federal Medical Research Center n. a. V.A. Almazov
Russian Federation

Ulitin Alexey Uyrjevich – MD, PhD, Professor, Director.

Mayakovskogo Str., St Petersburg 191014



A. V. Koloteva
Russian Polenov Neurosurgical Institute – a branch of North-Western Federal Medical Research Center n. a. V.A. Almazov
Russian Federation

Koloteva Anna Valerjevna – MD, Intern at the Almazov NMRC.

Mayakovskogo Str., St Petersburg 191014



References

1. Zenkov L. R. Clinical epileptology [Klinicheskaya epileptologiya (in Russian)]. 2010; Moscow. 408 s.

2. Ayvazyan S. O., Shiryaev Yu.S. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2016; 8: 22-28. DOI: 10.17749/20778333.2016.8.1.022-028.

3. Karlov V. A. Epilepsy [Epilepsiya (in Russian)]. Moscow. 1990; 336.

4. Kissin M. Ya. Clinical epileptology [Klinicheskaya epileptologiya (in Russian)]. Moscow. 2011; 256 s.

5. Odintsova G. V., Koroleva N. Yu., Chugunova A. A., Saykova L. A. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2014; 6 (2): 12-18.

6. Broun T., Holms G. Epilepsy. Clinical guidelines: Trans. with English. Ed. prof. K. Yu. Mukhin [Epilepsiya. Klinicheskoe rukovodstvo: Per. s angl. Pod red. prof. K.YU. Muhina (in Russian)]. Moscow. 2014; 280 s.

7. Shershever A. S. Surgical treatment of epilepsy [Hirurgicheskoe lechenie epilepsii (in Russian)]. Ekaterinburg. 2005; 164 s.

8. Grinenko A. O., Golovteev AL., Koptelova A. L., Vorob’ev A.N, Bychenko V.G, Dorofeeva M. Yu., Troitskiy A. A., Korsakova M. B., Kozlova A. B., Arhipova N. A., Stroganova T. A. Vestnik epideptologii (in Russian). 2014; 1 (2): 7-20.

9. Imankulov S. A. Zdravoohranenie Kyrgyzstana (in Russian). 2014; 2: 78-84.

10. Stepanenko A. Yu. Nerohirurgiya (in Russian). 2012; 78-84.

11. Kariev G. M., Yakubov Zh.B. Zhurnal teoreticheskoy i klinicheskoy meditsiny (in Russian). 2014; 4: 56-62.

12. Yakovenko I. V., Ivanova N. E., Kondakov E. N., Ulitin A. Yu. Translyatsionnaya meditsina (in Russian). 2015; 5: 30-38.

13. Odintsova G. V., Kuralbaev A. K., Nezdorovina V. G., Abramov K. B., Pavlovskaya M. E., Telegina A. A., Bersnev V. P. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2017; 9 (2): 41-49. DOI:10.17749/2077-8333.2017.9.2.041-049.

14. Hachatryan R. G., Odintsova G. V., Don O. A., Kim A. V., Telegina A. A., Ivanov A. Yu., Ivanova N. E., Hachatryan V. A. Kazanskiy meditsinskiy zhurnal (in Russian). 2018; 99 (1): 96-99.

15. Lebedev K. E., Mamathanov M. R. Neyrohirurgiya detskogo vozrasta (in Russian). 2016; 2: 66-78.

16. Schramm J. Epilepsy Surgery and the Evolution of Clinical and Translational Science. Neurosurgery. 2014; 61: 54-65.

17. Engel J. et al. Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy . JAMA. 2012; 307 (9): 922.

18. Nikitina M. A., Muhin K. Yu., Gluhova L. Yu., CHadaev V. A. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2015; 7 (2): 59-64.

19. Odintsova G. V., Aleksandrov M. V., Ulitin A. YU., Koloteva A. V. Translyatsionnaya meditsina (in Russian). 2018; 5: 30-37. DOI: 10.18705/2311-4495-2018-5-2-30-37.

20. Krylov V. V. et al. Zhurnal nevrologii i pskhiatrii im. S. S. Korsakova (in Russian). 2016; 5: 13-18.

21. Helmstaedter C., Witt J.-A. Clinical neuropsychology in epilepsy. Handbook of clinical neurology. 2012; 1: 437-459.


For citation:


Odintsova G.V., Aleksandrov M.V., Ulitin A.Y., Koloteva A.V. Duration of epilepsy and severity of the disease in neurosurgical patients. Epilepsia and paroxyzmal conditions. 2018;10(3):44-51. (In Russ.) https://doi.org/10.17749/2077-8333.2018.10.3.044-051

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)