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Non-invasive assessment of the effective dose of lamotrigine and topiramate for the treatment of epileptiform states in rats

https://doi.org/10.17749/2077-8333.2019.11.2.142-152

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Abstract

Aim. This study was aimed to test the instrumental complex called «Bioscope» for its ability to determine the optimal dose of the anticonvulsant drugs lamotrigine and topiramate in the treatment of epileptiform states.

Materials and methods. The experiments were conducted with 40 mongrel white male rats weighing 180-220g. In total, there were 5 series of experiments where different doses of lamotrigine and topiramate were used. The integrative state of the animals (as determined with the Bioscope) was monitored, first at the baseline and then after the anti-epileptic drug administration and subsequently after the administration of corazol.

Results. The Bioscope signals changed with changing doses of the anticonvulsant drugs. Low doses did not affect the integrative indicators, while the increasing doses caused these indicators to change. In dependence on the anticonvulsant drug dose, the administration of corasol either brought the integrative indicators back to the baseline or did not change them at all.

Conclusion. The Bioscope instrumental complex can be used for the non-invasive evaluation of the effective dose of anticonvulsant drugs needed to suppress the epileptiform states in rats.

About the Authors

R. G. Paronikyan
The Institute of fine organic chemistry named after A. L. Mnjoyan scientific-technological center of organic and pharmaceutical chemistry, NAS of Republic of Armenia
Armenia

Ruzanna G. Paronikyan - PhD, Associate Professor, Senior Researcher, Institute of Fine Organic Chemistry.

26 Azatutyan Ave., Erevan 0014



R. Sh. Sargsyan
Institute of Physiology named after L.A. Orbeli
Armenia

Rafik Sh. Sarkisyan - PhD, Professor, Head of the Laboratory of Integrative Biology.

22 Bratyev Orbeli Str., Yerevan



M. N. Avagyan
Institute of Surgery Mikaelyan
Russian Federation

Mkrtich N. Avagyan - MD, Associate Professor, Head of the “AltMed” Center of Rehabilitation and Traditional Medicine.

9, Asratyan Str., Yerevan 0052



M. S. Grigoryan
The Institute of fine organic chemistry named after A. L. Mnjoyan scientific-technological center of organic and pharmaceutical chemistry, NAS of Republic of Armenia
Russian Federation

Marinе S. Grigoryan - Junior Researcher.

26 Azatutyan Ave., Erevan 0014


A. L. Kostanyan
Institute of Physiology named after L.A. Orbeli
Armenia

AsmikL. Kostanyan - Junior Researcher at the Laboratory of Integrative Biology.

22 Bratyev Orbeli Str., Yerevan


N. D. Paronikyan
American University of Armenia
Armenia

Naira D. Paronikyan - BA Student.

40 Marshala Bagramyana, Str., Yerevan 0019



V. M. Avagyan
Institute of Surgery Mikaelyan
Armenia

Vahan M. Avagyan - MD, Associate Professor, Head of the Department of Rehabilitation and Traditional Medicine.

9, Asratyan Str., Yerevan 0052



L. S. Vardanyan
Institute of Surgery Mikaelyan
Armenia

Lusine Sh. Vardanyan - MD, Practicing Physician, Department of Rehabilitation and Traditional Medicine.

9, Asratyan Str., Yerevan 0052


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For citation:


Paronikyan R.G., Sargsyan R.S., Avagyan M.N., Grigoryan M.S., Kostanyan A.L., Paronikyan N.D., Avagyan V.M., Vardanyan L.S. Non-invasive assessment of the effective dose of lamotrigine and topiramate for the treatment of epileptiform states in rats. Epilepsy and paroxysmal conditions. 2019;11(2):142-152. (In Russ.) https://doi.org/10.17749/2077-8333.2019.11.2.142-152

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)