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Vagus Nerve Stimulator implantation in a pregnant woman with drug resistant epilepsy

https://doi.org/10.17749/2077-8333.2019.11.4.388-394

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Abstract

The aim is to present a case of successful implantation of Vagus Nerve Stimulator (VNS) in a woman with drug resistant epilepsy (DRE) during pregnancy. It is the first case of VNS implantation in the Russian Federation. The implantation, follow-up, and programming were carried out in the Bekhterev National Research Medical Centre of Psychiatry and Neurology, Saint-Petersburg.

Material and method. Female patient, 28 y.o., was diagnosed with DRE more than 11 years ago. The course of her epilepsy deteriorated during pregnancy despite of the appropriate antiepileptic treatment. The EEG, MRI, and laboratory tests did not reveal any focal brain lesion that could necessitate surgical resection. After multidisciplinary consultations, no contraindications to VNS procedure were found.

Results. The VNS system was implanted in this patient when she was 18-week-pregnant. The procedure resulted in a seizure reduction and allowed the patient to preserve her pregnancy and deliver a healthy child.

Conclusions. VNS Therapy® is safe and effective for the treatment of DRE. This successful case of VNS implantation in pregnancy opens new venues for the treatment of DRE in this group of patients. 

The authors declare the absence of conflict of interest with respect to this publication. All authors contributed equally to this article.

About the Authors

M. N. Klochkov
Bekhterev National Medical Research Center of Psychiatry and Neurology
Russian Federation
Michael N. Klochkov – MD, Neurologist, Department of Neurosurgery


S. A. Katyshev
Bekhterev National Medical Research Center of Psychiatry and Neurology
Russian Federation
Sergey A. Katyshev – MD, Neurosurgeon & Psychiatrist, Department of Neurosurgery


A. V. Vtorov
Bekhterev National Medical Research Center of Psychiatry and Neurology
Russian Federation
Alexander V. Vtorov – MD, Head of the Department of Neurosurgery


M. M. Bondareva
Bekhterev National Medical Research Center of Psychiatry and Neurology
Russian Federation
Maria M. Bondareva – MD, Junior Researcher, Department of Neurosurgery


T. A. Skoromets
Bekhterev National Medical Research Center of Psychiatry and Neurology
Russian Federation
Taras A. Skoromets – MD, PhD, Chief Researcher & Supervisor, Department of Neurosurgery


A. G. Naryshkin
Bekhterev National Medical Research Center of Psychiatry and Neurology; Sechenov Institute of evolutionary physiology and biochemistry Russian Academy of Sciences; Mechnikov Northwestern State Medical University
Russian Federation
Alexander G. Naryshkin – MD, PhD, Leading Researcher, Department of Neurosurgery, Bekhterev National Medical Research Center of Psychiatry and Neurology; Leading Researcher, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences; Professor at the Polenov Department of Neurosurgery,


A. A. Feygina
LLC “Sorin Group Rus”, official representative “LivaNova” in Russia
Russian Federation
Anna A. Feygina – MD, PhD, Neurologist, Medical Science Liaison Manager, Neuromodulation, Russia, LLC “Sorin Group Rus”, Authorized Representative of “LivaNova”.


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For citation:


Klochkov M.N., Katyshev S.A., Vtorov A.V., Bondareva M.M., Skoromets T.A., Naryshkin A.G., Feygina A.A. Vagus Nerve Stimulator implantation in a pregnant woman with drug resistant epilepsy. Epilepsy and paroxysmal conditions. 2019;11(4):388-394. (In Russ.) https://doi.org/10.17749/2077-8333.2019.11.4.388-394

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)