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MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN

https://doi.org/10.17749/2077-8333.2016.8.1.022-028

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Abstract

Treatment of drug-resistant epilepsy is an extremely difficult task. Unfortunately, in Russia there are no regulations containing the algorithm of actions to help the practical neurologist in management of drug-resistant patients. It is obvious that there is an urgent need to establish a network of specialized epilepsy centers of level 4 (classification of the National Association of Epilepsy Centers, USA) in the territory of the Russian Federation, united by a common ideology and methodology.

Objective: to increase the quality of care for patients with refractory forms of epilepsy, by combined use of non-drug treatments such as surgery, ketogenic diet and chronic vagus nerve stimulation (VNS Therapy).

Material and methods. We observed 168 patients aged 1 to 18 years with refractory epilepsy.

Results. Surgical treatment was performed in 63 patients, ketogenic diet — 73, VNS therapy — 32 patients. Analysis of the combined effectiveness showed the following results: complete seizure control was observed in 59 (35.1%) patients; reducing the number of seizures of more than 75% — in 19 (11.3%), 50% — and 53 (31.5%), no effect, — 37 (22%). Thus, the significant improvement was observed on the whole in 131 (78%) patients of 168. Conclusions. An integrated approach, involving a differentiated choice of a non-drug treatment allows to achieve significant positive results, despite the resistance of epilepsy to drug therapy.

About the Authors

S. O. Ayvazyan
Scientific-Practical Center of Medical Care of Children, Moscow Health Department Medical Center «Nevromed», Moscow
Russian Federation

PhD, leading researcher, Scientific-Practical Center of Medical Care of Children, Moscow Health Department. Address: Str. Aviators, 38, Moscow, Russia, 119620. Tel.: +7(495)4392710; head of the Epileptology Department, Medical Center «Nevromed». Address: Ul. Shabolovka, 34, Moscow, 115419. Tel.: +7(495)6019004



Yu. S. Shiryaev
Scientific-Practical Center of Medical Care of Children, Moscow Health Department
Russian Federation

PhD, researcher, Scientific-Practical Center of Medical Care of Children, Moscow Health Department. Address: ul. Aviatorov, 38, Moscow, Russia, 119620. Tel.: +7(495)4392710



References

1. The National Association of epilepsy centers in the USA (NAEC). URL: http://www.naeclocator.org/locator/resultsall.asp. Accessed: 24.09.2015.

2. Usacheva E. L., Aivazyan S. O., Sorvacheva T. N., Pyr’eva E.A., Shorina M. Yu. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova. 2004; 7: 29-34.

3. National Association of Epilepsy Centers, Minneapolis, Minnesota, U.S.A. Guidelines for essential services, personnel, and facilities in specialized epilepsy centers. 2010.

4. World Health Organization. URL: http://www.who.int/ru/. Accessed: 24.09.2015.

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For citation:


Ayvazyan S.O., Shiryaev Y.S. MODERN TREATMENT OF DRUG-RESISTANT EPILEPSY, AVAILABLE IN RUSSIAN. Epilepsy and paroxysmal conditions. 2016;8(1):22-28. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.1.022-028

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)