Preview

Epilepsy and paroxysmal conditions

Advanced search

Psychogenic nonepileptic seizures: to the issue of diagnosis and patient management (with a case report)

https://doi.org/10.17749/2077-8333/epi.par.con.2021.056

Abstract

Establishing misdiagnosis “epilepsy” is a common event comprising 25% total cases of “pharmacoresistant” forms. Eventually, the majority of cases resulted in diagnosing psychogenic nonepileptic seizures, or functional seizures, conversion seizures, and dissociative seizures. Here we review publications assessing psychogenic non-epileptic seizures. The scientific resources for analysis were selected in Russian (eLibrary) and international (Pubmed/MEDLINE, Google Scholar) databases, as well as in open access resources. We also present a clinical case of a patient diagnosed with epilepsy. In particular, the patient was admitted to the hospital with complains of paroxysmal conditions starting as headache, nausea proceeding with speech arrest and decreased mindfulness of what happens in personal life. He also informed about at least two episodes of disorientation described as “missed public transport stop” and “finding himself in unfamiliar place”. The patient underwent examination (electroencephalography, brain magnetic resonance imaging) and dynamic follow-up to verify origin of such conditions. As a result, he was diagnosed with psychogenic non-epileptic seizures. Administering proper therapy allowed to achieve stabilized condition and arrest seizures. The criteria provided in the review as well as clinical case report may help clinical practitioners to timely conduct differential diagnostics and deliver specialized medical aid.

About the Authors

N. I. Shova
Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation

Natalia I. Shova – Postgraduate Student

Scopus Author ID: 57215893698; RSCI SPIN-code: 1952-3043

3 Bekhtereva Str., Saint Petersburg 192019



D. V. Alekseeva
Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation

Diana V. Alekseeva – Junior Researcher, Department for the Treatment of Patients with Exogenous Organic Disorders and Epilepsy

Scopus Author ID: 57216917954; RSCI SPIN-code: 2331-8682

3 Bekhtereva Str., Saint Petersburg 192019



V. A. Mikhailov
Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation

Vladimir A. Mikhailov – Dr. Med. Sc., Deputy Director for Innovative Scientific Development, Head of the International Department, Chief Researcher and Scientific Director of the Department of Treatment of Organic Mental Disorders and Epilepsy and Rehabilitation of Patients with Psychosomatic Disorders

WoS ResearcherID: B-3272-2017; RSCI SPIN-code: 5563-1009

3 Bekhtereva Str., Saint Petersburg 192019



References

1. Benbadis S.R., Tatum W.O. Overintepretation of EEGs and misdiagnosis of epilepsy. J Clin Neurophysiol. 2003; 20 (1): 42–4. https://doi.org/10.1097/00004691-200302000-00005.

2. Benbadis S.R. Errors in EEGs and the misdiagnosis of epilepsy: importance, causes, consequences, and proposed remedies. Epilepsy Behav. 2007; 11 (3): 257–62. https://doi.org/10.1016/j.yebeh.2007.05.013.

3. Benbadis S.R., Lin K. Errors in EEG interpretation and misdiagnosis of epilepsy. Which EEG patterns are overread? Eur Neurol. 2008; 59 (5): 267–71. https://doi.org/10.1159/000115641.

4. Goetz C.G. Charcot, hysteria, and simulated disorders. Handb Clin Neurol. 2016; 139: 11–23. https://doi.org/10.1016/B978-0-12-801772-2.00002-3.

5. Koby D.G., Zirakzadeh A., Staab J.P., et al. Questioning the role of abuse in behavioral spells and epilepsy. Epilepsy Behav. 2010; 19 (4): 584–90. https://doi.org/10.1016/j.yebeh.2010.09.014.

6. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-5®). Washington, DC: American Psychiatric Publishing; 2013.

7. Duncan R., Razvi S., Mulhern S. Newly presenting psychogenic nonepileptic seizures: incidence, population characteristics, and early outcome from a prospective audit of a first seizure clinic. Epilepsy Behav. 2011; 20 (2): 308–11. https://doi.org/10.1016/j.yebeh.2010.10.022.

8. Benbadis S.R., O’Neill E., Tatum W.O., Heriaud L. Outcome of prolonged video-EEG monitoring at a typical referral epilepsy center. Epilepsia. 2004; 45 (9): 1150–3. https://doi.org/10.1111/j.0013-9580.2004.14504.x.

9. Reuber M., Pukrop R., Mitchell A.J., et al. Clinical significance of recurrent psychogenic nonepileptic seizure status. J Neurol. 2003; 250 (11): 1355–62. https://doi.org/10.1007/s00415-003-0224-z.

10. Benbadis S.R., LaFrance W.C. Jr., Papandonatos G.D., et al. NES Treatment Workshop. Interrater reliability of EEG-video monitoring. Neurology. 2009; 73 (11): 843–6. https://doi.org/10.1212/WNL.0b013e3181b78425.

11. Mellers J.D. The approach to patients with “non-epileptic seizures”. Postgrad Med J. 2005; 81 (958): 498–504. https://doi.org/10.1136/pgmj.2004.029785.

12. Meierkord H., Will B., Fish D., Shorvon S. The clinical features and prognosis of pseudoseizures diagnosed using video-EEG telemetry. Neurology. 1991; 41 (10): 1643–6. https://doi.org/10.1212/wnl.41.10.1643.

13. Leis A.A., Ross M.A., Summers A.K. Psychogenic seizures: ictal characteristics and diagnostic pitfalls. Neurology. 1992; 42 (1): 95–9. https://doi.org/10.1212/wnl.42.1.95.

14. DeToledo J.C., Ramsay R.E. Patterns of involvement of facial muscles during epileptic and nonepileptic events: review of 654 events. Neurology. 1996; 47 (3): 621–5. https://doi.org/10.1212/wnl.47.3.621.

15. Reuber M., Elger C.E. Psychogenic nonepileptic seizures: review and update. Epilepsy Behav. 2003; 4 (3): 205–16. https://doi.org/10.1016/s1525-5050(03)00104-5.

16. LaFrance W.C. Jr., Reuber M., Goldstein L.H. Management of psychogenic nonepileptic seizures. Epilepsia. 2013; 54 (Suppl. 1): 53–67. https://doi.org/10.1111/epi.12106.

17. Hingray C., Biberon J., El-Hage W., de Toffol B. Psychogenic nonepileptic seizures (PNES). Rev Neurol (Paris). 2016; 172 (4–5): 263–9. https://doi.org/10.1016/j.neurol.2015.12.011.

18. Huff J.S., Murr N. Psychogenic nonepileptic seizures. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.

19. Myers L., Perrine K., Lancman M., et al. Psychological trauma in patients with psychogenic nonepileptic seizures: trauma characteristics and those who develop PTSD. Epilepsy Behav. 2013; 28 (1): 121–6. https://doi.org/10.1016/j.yebeh.2013.03.033.

20. Willment K., Hill M., Baslet G., Loring D.W. Cognitive impairment and evaluation in psychogenic nonepileptic seizures: an integrated cognitive-emotional approach. Clin EEG Neurosci. 2015; 46 (1): 42–53. https://doi.org/10.1177/1550059414566881.

21. Asadi-Pooya A.A. Psychogenic nonepileptic seizures: a concise review. Neurol Sci. 2017; 38 (6): 935–40. https://doi.org/10.1007/s10072-017-2887-8.

22. Martlew J., Pulman J., Marson A.G. Psychological and behavioural treatments for adults with non-epileptic attack disorder. Cochrane Database Syst Rev. 2014; 2: CD006370. https://doi.org/10.1002/14651858.CD006370.pub2.

23. LaFrance W.C. Jr., Deluca M., Machan J.T., Fava J.L. Traumatic brain injury and psychogenic nonepileptic seizures yield worse outcomes. Epilepsia. 2013; 54 (4): 718–25. https://doi.org/10.1111/epi.12053.

24. Duncan R. Psychogenic nonepileptic seizures: EEG and investigation. Handb Clin Neurol. 2016; 139: 305–11. https://doi.org/10.1016/B978-0-12-801772-2.00027-8.

25. Gedzelman E.R., LaRoche S.M. Long-term video EEG monitoring for diagnosis of psychogenic nonepileptic seizures. Neuropsychiatr Dis Treat. 2014; 10: 1979–86. https://doi.org/10.2147/NDT.S49531.

26. Amin U., Benbadis S.R. The role of EEG in the erroneous diagnosis of epilepsy. J Clin Neurophysiol. 2019; 36 (4): 294–7. https://doi.org/10.1097/WNP.0000000000000572.


Review

For citations:


Shova N.I., Alekseeva D.V., Mikhailov V.A. Psychogenic nonepileptic seizures: to the issue of diagnosis and patient management (with a case report). Epilepsy and paroxysmal conditions. 2021;13(2):147-156. (In Russ.) https://doi.org/10.17749/2077-8333/epi.par.con.2021.056

Views: 1173


ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)