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Reiterating the role of corpus callosum in generalization of interictal and ictal epileptiform discharges: a case report with post-callosotomy intracranial electroencephalography in Lennox–Gastaut syndrome

https://doi.org/10.17749/2077-8333/epi.par.con.2021.086

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Abstract

Lennox–Gastaut syndrome (LGS) is an epileptic encephalopathy characterized by delayed mental development and intractable multiple seizure types, predominantly tonic. Drop attacks are the commonest and the most disabling type of seizures. Resective surgery is often not possible in LGS as the electroencephalogram (EEG) abnormalities are usually multifocal and generalized, and magnetic resonance image is often either normal or multilesional. We report a case of LGS with bilateral parieto-occipital gliosis where EEG before and after callosotomy demonstrated synchronized bilateral interictal epileptiform discharges and ictal discharges becoming desynchronized and running down. This phenomenon emphasizes the role of the corpus callosum in secondary bilateral synchrony.

About the Authors

S. Gopinath
Amrita Advanced Centre for Epilepsy, Amrita Institute of Medical Science
India

Siby Gopinath – MD, Clinical Professor, Department of Neurology

Ponekkara, P.O, Kochi, Kerala 682041



A. Pillai
Amrita Advanced Centre for Epilepsy, Amrita Institute of Medical Science
India

Ashok Pillai – MD, Professor, Department of Neurosurgery

Ponekkara, P.O, Kochi, Kerala 682041



A. G. Diwan
Narayani Hospital
India

Anand G. Diwan – MD, Consultant Neurologist

Mumbai Naka, Shri Vallabh Nagar, Nashik, Maharashtra 422006



J. V. Pattisapu
University of Central Florida College of Medicine; Arnold Palmer Hospital for Children
United States

Jogi V. Pattisapu – MD, Emeritus Medical Director, Pediatric Neurosciences

6850 Lake Nona Blvd., Orlando, Fl 32827

92 W Miller Str., Orlando, FL 32806

 



K. Radhakrishnan
Amrita Advanced Centre for Epilepsy, Amrita Institute of Medical Science
Russian Federation

Kurupath Radhakrishnan – MD, Professor

Ponekkara, P.O, Kochi, Kerala 682041



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For citation:


Gopinath S., Pillai A., Diwan A.G., Pattisapu J.V., Radhakrishnan K. Reiterating the role of corpus callosum in generalization of interictal and ictal epileptiform discharges: a case report with post-callosotomy intracranial electroencephalography in Lennox–Gastaut syndrome. Epilepsy and paroxysmal conditions. 2021;13(3):249-253. https://doi.org/10.17749/2077-8333/epi.par.con.2021.086

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)