Reiterating the role of corpus callosum in generalization of interictal and ictal epileptiform discharges: a case report with post-callosotomy intracranial electroencephalography in Lennox–Gastaut syndrome
https://doi.org/10.17749/2077-8333/epi.par.con.2021.086
Abstract
Lennox–Gastaut syndrome (LGS) is an epileptic encephalopathy characterized by delayed mental development and intractable multiple seizure types, predominantly tonic. Drop attacks are the commonest and the most disabling type of seizures. Resective surgery is often not possible in LGS as the electroencephalogram (EEG) abnormalities are usually multifocal and generalized, and magnetic resonance image is often either normal or multilesional. We report a case of LGS with bilateral parieto-occipital gliosis where EEG before and after callosotomy demonstrated synchronized bilateral interictal epileptiform discharges and ictal discharges becoming desynchronized and running down. This phenomenon emphasizes the role of the corpus callosum in secondary bilateral synchrony.
About the Authors
S. GopinathIndia
Siby Gopinath – MD, Clinical Professor, Department of Neurology
Ponekkara, P.O, Kochi, Kerala 682041
A. Pillai
India
Ashok Pillai – MD, Professor, Department of Neurosurgery
Ponekkara, P.O, Kochi, Kerala 682041
A. G. Diwan
India
Anand G. Diwan – MD, Consultant Neurologist
Mumbai Naka, Shri Vallabh Nagar, Nashik, Maharashtra 422006
J. V. Pattisapu
United States
Jogi V. Pattisapu – MD, Emeritus Medical Director, Pediatric Neurosciences
6850 Lake Nona Blvd., Orlando, Fl 32827
92 W Miller Str., Orlando, FL 32806
K. Radhakrishnan
Russian Federation
Kurupath Radhakrishnan – MD, Professor
Ponekkara, P.O, Kochi, Kerala 682041
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Review
For citations:
Gopinath S., Pillai A., Diwan A.G., Pattisapu J.V., Radhakrishnan K. Reiterating the role of corpus callosum in generalization of interictal and ictal epileptiform discharges: a case report with post-callosotomy intracranial electroencephalography in Lennox–Gastaut syndrome. Epilepsy and paroxysmal conditions. 2021;13(3):249-253. https://doi.org/10.17749/2077-8333/epi.par.con.2021.086
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