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Treatment of epilepsy associated with primary and metastatic brain tumors


There is a number of unsolved issues in management of epilepsy associated with primary and metastatic brain tumors (BTs). In particular, no consensus approaches to treatment of patients with epilepsy associated with BTs have been proposed regarding use of current anti-epileptic drugs (AEDs). The review presents the relevant data on epidemiology, features of clinically manifested epilepsy at varying stages of BTs, aspects of drug-drug interaction between AEDs and anti-tumor agents, AED-related effects on cognitive functions as well as quality of life in patients with epilepsy associated with BTs. Levetiracetam and valproic acid comprise the first-line drugs for treating seizures in patients with BTs. It is unreasonable to use AEDs acting as hepatic microsomal enzyme inducers for therapy of epileptic seizures in BTs, because it may decrease efficacy of chemotherapy agents and glucocorticoids along with elevated rate of side effects. Perampanel acting as a selective noncompetitive AMPA receptor antagonist, may be one of the drugs of choice for the adjunctive therapy of epileptic seizures associated with BTs.

About the Authors

A V. Lebedeva
Pirogov Russian National Research Medical University; Research Institute of Healthcare Organization and Medical Management
Russian Federation

Anna V. Lebedeva – Dr. Med. Sc., Professor, Chair of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine; Head of Organizational and Methodological Department of Neurology

1 Ostrovityanov Str., Moscow 117997

9 Sharikopodshipnikovskaya Str., Moscow 115088

RSCI SPIN-code: 3515-2408

S. G. Burd
Pirogov Russian National Research Medical University; Federal Center for Brain and Neurotechnology
Russian Federation

Sergey G. Burd – Dr. Med. Sc., Professor, Chair of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine; Head of Department of Epilepsy and Paroxysmal Conditions

1 Ostrovityanov Str., Moscow 117997

1 bld. 10 Ostrovityanov Str., Moscow 117513

RSCI SPIN-code: 1484-0178

P. N. Vlasov
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Pavel N. Vlasov – Dr. Med. Sc., Professor, Chair of Nervous Diseases

20/1 Delegatskaya Str., Moscow 127473

Scopus Author ID: 7101688064

RSCI SPIN-code: 9357-2284

N. A. Ermolenko
Burdenko Voronezh State Medical University; Voronezh Regional Children's Clinical Hospital No. 1
Russian Federation

Natalia A. Ermolenko – Dr. Med. Sc., Chief of Chair of Neurology No. 1; Head of Neurological Department No. 2

10 Studencheskaya Str., Voronezh 394036

1 Burdenko Str., Voronezh 394024

RSCI SPIN-code: 8604-1145

I. A. Zhidkova
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Irina A. Zhidkova – Dr. Med. Sc., Professor, Chair of Nervous Diseases

20/1 Delegatskaya Str., Moscow 127473

RSCI SPIN-code: 5498-6921

S. K. Zyryanov
Peoples’ Friendship University of Russia; City Clinical Hospital No. 24
Russian Federation

Sergey K. Zyryanov – Dr. Med. Sc., Professor, Chief of Chair of General and Clinical Pharmacology; Deputy Chief Physician for Therapy

8 corp. 2 Miklukho-Maklay Str., Moscow 117198

10 Pistsovaya Str., Moscow 127015

RSCI SPIN-code: 2725-9981

I. Yu. Kovaleva
Pirogov Russian National Research Medical University
Russian Federation

Irina Yu. Kovaleva – MD, PhD, Professor, Chair of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine

1 Ostrovityanov Str., Moscow 117997


D. R. Naskhletashvili
Blokhin National Medical Research Center of Oncology
Russian Federation

David R. Naskhletashvili – MD, PhD, Senior Researcher, Neurosurgical Department, Research Institute of Clinical Oncology

24 Kashirskoye Hwy, Moscow 115478

RSCI SPIN-code: 3038-5710

N. Yu. Perunova
Medical Center "Neurology
Russian Federation

Natalia Yu. Perunova – Dr. Med. Sc., Neurologist, Epileptologist, Neurology Medical Center

52 Amundsen Str., Ekaterinburg 620146


I. G. Rudakova
Vladimirskiy Moscow Regional Research Clinical Institute
Russian Federation

Irina G. Rudakova – Dr. Med. Sc., Professor, Chair of Neurology

61/2 bld. 6 Shchepkin Str., Moscow 129110

RSCI SPIN-code: 3832-4770

R. K. Shikhkerimov
Polyclinic No. 4, Department of Affairs of the President of the Russian Federation; City Polyclinic No. 166
Russian Federation

Rafiz K. Shikhkerimov – Dr. Med. Sc., Neurologist

20 Kutuzovskiy Ave, Moscow 121151

9 Domodedovskaya Str., Moscow 115551

RSCI SPIN-code: 6191-5433

M. A. Yamin
Regional Consultative and Diagnostic Center; Rostov State Medical University
Russian Federation

Maksim A. Yamin – MD, PhD, Head of Regional Epileptology Center; Assistant Professor, Chair of Personalized and Translational Medicine

127 Pushkinskaya Str., Rostov-on-Don 344000

29 Nakhichevanskiy Aly,Rostov-on-Don 344022

RSCI SPINcode: 3726-5656


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For citations:

Lebedeva A.V., Burd S.G., Vlasov P.N., Ermolenko N.A., Zhidkova I.A., Zyryanov S.K., Kovaleva I.Yu., Naskhletashvili D.R., Perunova N.Yu., Rudakova I.G., Shikhkerimov R.K., Yamin M.A. Treatment of epilepsy associated with primary and metastatic brain tumors. Epilepsy and paroxysmal conditions. 2021;13(3):286-304. (In Russ.)

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ISSN 2311-4088 (Online)