NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY
https://doi.org/10.17749/2077-8333.2016.8.1.050-054
Abstract
Neurodevelopmental disorders, including intellectual disability, autistic-spectrum disorders, speech and language disorders, attention deficit hyperactivity disorder (ADHD), learning disabilities, are more prevalent in children with epilepsy compared with their peers. Marked developmental delay and regression of acquired skills are typical for epileptic encephalopathies. On the other hand, neurodevelopmental disorders associated with epileptiform activity on the EEG without any clinical manifestations of epileptic fits, represent a serious problem. The causes of neurodevelopmental disorders in children with epilepsy are discussed, as well as clinical features of some epilepsies, associated with neurodevelopmental disorders.
About the Author
N. N. Zavadenko
Pirogov Russian National Research Medical University of the Russian Federation Ministry of Heath
Russian Federation
Russian Federation
MD, PhD, neurologist, Professor, Head of the Neurology, Neurosurgery and Medical Genetics Department, Pediatric Faculty, Pirogov Russian National Research Medical University. Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997. Tel.: +7(495)6950229
References
1. Belousova E. D., Ermakov A. Yu. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova. 2014; 114 (4-2): 52-58.
2. Zavadenko N. N., Kozlova E. V., Shchederkina I. O., Trepilets V. M., Trepilets S. V., Kholin A. A. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova. 2014; 114 (4-2): 11-17.
3. Zavadenko N. N. Rossiiskii vestnik perinatologii i pediatrii. 2015; 60 (5): 6-13.
4. Zenkov L. R. Non-paroxysmal epileptic disorders. Moscow. 2007; 278 s.
5. Karlov V. A. Epilepsy in children and adult women and men. Guidelines for doctors. Moscow. 2010; 719 s.
6. Mutovin G. R., Zhilina S. S., Zavadenko N. N., Belenikin M. S. Signs and diseases with traditional and non-traditional inheritance. Moscow. 2015; 100 s.
7. Troitskaya L. A. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova. 2005; 105 (8): 91-98.
8. Kholin A. A. Status epilepticus in infancy and early childhood. Dr. diss. [Epilepticheskii status v mladencheskom i rannem detskom vozraste. Avtoref. diss. …dokt. med. nauk (In Russian)]. Moscow. 2010; 48 s.
9. Doose H., Baier W. K. Benign partial epilepsy and related conditions: multifactorial pathogenesis with hereditary impairment of brain maturation. Eur. J. Pediatr. 1989; 149: 152-158.
10. Duvelleroy-Hommet C., Billard C., Lucas B., Gillet P., Barthez M. A., Santini J. J., Degiovanni E., Henry F., De Toffol B., Autret A. Sleep EEG and developmental dysphasia: lack of a consistent relationship with paroxysmal EEG activity during sleep. Neuropediatrics. 1995; 26: 14-18.
11. Fisher R. S., Acevedo C., Arzimanoglou A., Bogacz A., Cross H. et al. A practical clinical definition of epilepsy. Epilepsia. 2014; 55: 475-482.
12. Guerrini R. Epilepsy in children. Lancet. 2006; 11; 367 (9509): 499-524
13. Neuschlova L., Šterbova K., Žackova J., Komarek V. Epileptiform activity in children with developmental dysphasia: quantification of discharges in overnight sleep video-EEG. Epileptic Disord. 2007; 9: 1: 28-35.
14. Panayiotopoulos C. P. A Clinical Guide to Epileptic Syndromes and their Treatment. London: Springer-Verlag, 2010, 578 p.
15. Picard A., Cheliout-Heraut F., Bouskraoui M., Lemoine M., Lacert P., Delattre J. Sleep EEG and developmental dysphasia. Dev Med Child Neurol. 1998; 40: 595-599.
16. Rudolf G., Valenti M. P., Hirsch E., Szepetowski P. From rolandic epilepsy to continuous spike-and-waves during sleep and Landau-Kleffner syndromes: Insights into possible genetic factors. Epilepsia. 2009; 50 (7): 25-28.
17. Russ S. A., Larson K., Halfon N. A national profile of childhood epilepsy and seizure disorder. Pediatrics. 2012; 129 (2): 256-264.
18. Saltik S., Uluduz D., Cokar O., Demirbilek V. et al. A clinical and EEG study on idiopathic partial epilepsies with evolution into ESES spectrum disorders. Epilepsia. 2005; 46: 524-533.
19. Scheffer I. Autosomal dominant rolandic epilepsy with speech dyspraxia. Epileptic disorders. 2000; 2 (1): 19-22.
20. Sillanpaa M. Epilepsy in children: prevalence, disability, and handicap. Epilepsia. 1992; 33 (3): 444-449.
21. Tassinari C. A., Cantalupo G., Rios-Pohl L., Giustina E. D., Rubboli G. Encephalopathy with status epilepticus during slow sleep: «the Penelope syndrome». Epilepsia. 2009; 50 (7): 4-8.
22. Tuchman R. F., Rapin I., Shinnar S. Autistic and dysphasic children II: Epilepsy. Pediatrics. 1991; 88: 1219-1225.
23. Wirrell E., Livingston J. H. Epilepsy beginning in middle childhood. In: Childhood Epilepsy: Management from Diagnosis to Remission. Eds. Appleton R., Camfield P. New York. 2011; 29-72.
Review
For citations:
Zavadenko N.N. NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY. Epilepsy and paroxysmal conditions. 2016;8(1):50-54. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.1.050-054
Views:
1383
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
