EPILEPSY AND MIGRAINE: NEUROIMAGING AND NEUROPATHOPHYSIOLOGICAL PARALLELS
Abstract
The aim of this work was to elucidate the structural-metabolic and neuropathophysiological features of epilepsy and migraine, as these diseases share common pathogenetic mechanisms.
Materials and methods. Seventy patients with migraine and fifty-six with epilepsy conducted a study using diffusion tensor MRI. Proton spectroscopy performed on 28 patients with epilepsy and 22 with migraine.
Results. Data were obtained, indicating changes in fractional anisotropy and average diffusion coefficient and concentration of the main neurometabolites for epilepsy and migraine that characterize the commonality of the pathogenesis of these diseases.
Conclusion. The research results allowed to establish the leading role of the hippocampus in the realization paroxysmal states and their pathophysiological basis of the comorbidity.
About the Authors
V. V. Evstigneev
Belarusian Medical Academy of Postgraduate Education, Minsk
Belarus
Belarus
Evstigneev Viktor Vladimirovich – MD, professor of neurology and neurosurgery.
Address: ul. P. Brovki, 3, korp. 3, Minsk, Belarus, 220013
A. N. Michailov
Belarusian Medical Academy of Postgraduate Education, Minsk
Belarus
Belarus
Mikhailov Aleksandr Nikolaevich – MD, head of the department of radiation diagnosis.
Address: ul. P. Brovki, 3, korp. 3, Minsk, Belarus, 220013
O. V. Kistsen
Belarusian Medical Academy of Postgraduate Education, Minsk
Belarus
Belarus
Kisten Olga Vasilevna – MD, Associate Professor of Neurology and Neurosurgery.
Address: ul. P. Brovki, 3, korp. 3, Minsk, Belarus, 220013
K. A. Sadokcha
Belarusian Medical Academy of Postgraduate Education, Minsk
Belarus
Belarus
Sadokha Kristina Antonovna – PhD, Associate Professor of Neurology and Neurosurgery.
Address: ul. P. Brovki, 3, korp. 3, Minsk, Belarus, 220013
R. A. Sakovich
Belarusian Medical Academy of Postgraduate Education, Minsk
Belarus
Belarus
Sakovich Ruslan Antonovich – assistant of the department of radiation diagnosis.
Address: ul. P. Brovki, 3, korp. 3, Minsk, Belarus, 220013
References
1. Azimova Yu.E., Tabeeva G.R. Migraine and epilepsy (In Russian). Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2009; 1: 21-25.
2. Bulaev I.V., Kisten' O.V., Sakovich R.A., Evstigneev V.V. Magnetic resonance spectroscopy and tractography evaluating microstructural changes in the brain in epilepsy. Proceedings of the scientific-practical conference "Actual issues of radiation diagnosis." Minsk, 8-9 November 2012, Ed. YF Poloiko (In Russian). Minsk, 8-9 noyabrya 2012 g. Pod red. Yu.F. Poloiko. Minsk. 2012; 57-60.
3. Vasilenko A.V. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2013; 2: 56-57.
4. Evstigneev V.V., Kisten' O.V., Bulaev I.V., Sakovich R.A. Vestnik Kazakhskogo natsional'nogo meditsinskogo universiteta. Spetsializirovannyi vypusk. 2012; 19-21.
5. Evstigneev V.V., Sadokha K.A., Kisten' O.V., Sakovich R.A. Morpho-functional features of the clinical manifestations of migraine. Materials the XV International Conference "The main directions of pharmacotherapy in neurology." Sudak, 24-26 April 2013 under. Ed. CM. Kuznetsova. Morfo-funktsional'nye osobennosti klinicheskogo proyavleniya migreni (In Russian). Kiev. 2013; 264-265.
6. Zenkov L.R. Hippocampal formation. Neurophysiology. Ed. IK Georgieva AM Wayne (In Russian). Sofiya. Meditsina i fizkul'tura. 1987; 109-117.
7. Kisten' O.V., Evstigneev V.V. Transcranial magnetic stimulation in epileptology (In Russian). 2013; 368 s.
8. Kisten' O.V., Evstigneev V.V., Sakovich R.A., Bulaev I.V. Peculiarities of structural white matter abnormalities on clinical realization of epilepsy (In Russian). Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2013; 1: 15-21.
9. Odinak M.M., Bazilevich S.N. Availability and use of neuroimaging in epilepsy. Epileptology medicine of the 21st century. Under. Ed. EI Gusev, AB Hecht (In Russian). Moscow. 2009; 287-297.
10. Trufanov G.E. Magnetic resonance spectroscopy: A Guide for Physicians. Ed. GE Trufanova, LA Tyutin (In Russian). SPb. 2008; 239 s.
11. Tyutin L.A., Pozdnyakov A.V., Stukov L.A. Zhurnal Vestnik rentgenologii i radiologii. 1999; 5: 4-7.
12. Basser P.J., Pajevic S., Pierpaoli C. et al. In vivo fiber tractography using DT-MRI data. Magn. Reson. Med. 2000; 44: 625-632.
13. Cruccu G., Iannetti G.D., Marx J.J. et al. Brainstem reflex circuits revisited / Brain. 2005; 128 (2): 386-394.
14. Catani M., Howard R.J.., Pajevic S., Jones D.K. Virtual in vivo interactive dissection of white matter fascicule in the human brain. NeuroImage. 2002; 17: 77-94.
15. Cavazos J.E., Cross D.J. The role of synaptic reorganization in mesial temporal lobe epilepsy. Epilepsy Behav. 2006; 8 (3): 483-493.
16. Ciccarelli O., Catani M., Johansen-Berg H., Clark C., Thompson A. Diffusion-based tractography in neurological disorders: concepts, applications, and future developments. Lancet Neurol. 2008; 7: 715-727.
17. Charles A., Brennan K.C. Cortical spreading depression – new insights and persistent questions. Cephalalgia. 2009; 29:1115-1124.
18. Hadjikhani N., Sanchez Del Rio M., Wu O. et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA. 2001; 98: 4687-4692.
19. Izquierdo I. Hippocampal physiology: experiments of regulation of its electrical activity, on the mechanisms of seizures, and on a hypothesis of learning. Behav Biol. 1972; 5: 669-698.
20. Markram H., Toledo-Rodriguez M., Wang Y., Gupta A. et al. Interneurons of the neocortical inhibitory system. Nat Rev Neurosci. 2004: 5: 793-807.
21. Maton B.M., Kuzniecky R.I. Proton MRS: N-acetylaspartate, creatine, choline. Rev. Adv. Neurol. 2000; 83 (2): 253-259.
22. Miller F.P., Agnes F.V., McBrewster J. Epileptogenesis. VDM Publishing House Ltd., 2010. 152 p.
23. Silberstein S.D., Lipton R.B., Goatsby P.J. Headache in clinical practice. London. 2002. 211 p.
24. Evstigneev V.V., Kistsen V.V., Bulaev I.V., Sakovich R.A. The effect of structural white matter abnormalities on the clinical course of epilepsy. Adv Clin Exp Med. 2013; 22 (4): 529-537.
25. Vion-Dury J., Salvan A.M., Cozzone P.J. Proton magnetic resonance spectrometry for the non-invasive exploration of human brain metabolism: current and future clinical applications. Rev. Neurol. 1999; 155 (11): 903-926.
26. Yevstigneiev V., Kistsen O., Sadokha K., Sakovich R. Epilepsy and migraine: neuroimaging and neuropathophysiological parallels. Mezhdunarodnyi nevrologicheskii zhurnal. 2015; 1 (71): 12-18.
For citation:
Evstigneev V.V., Michailov A.N., Kistsen O.V., Sadokcha K.A., Sakovich R.A. EPILEPSY AND MIGRAINE: NEUROIMAGING AND NEUROPATHOPHYSIOLOGICAL PARALLELS. Epilepsy and paroxysmal conditions. 2015;7(3):18-25. (In Russ.)
Views: 264
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
