ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES
Abstract
We examined the clinical and genetic evaluation of SERT and TPH2 genes SNP polymorphisms role in the development of side effects during topiramate therapy taking into account gender features. Found significant differences in the severity of topiramate side effects in the nervous system and psycho-emotional sphere in patient groups with different variants of alleles, and identified gender features in elaboration of depression and emotional lability
About the Authors
A. S. Chukanova
Russian State Medical University named after N.I. Pirogov
Russian Federation
Department of Neurology and Neurosurgery
Russian Federation
Department of Neurology and Neurosurgery
M. A. Tushkanov
FSO, «Research Institute of Human Ecology and Environmental Hygiene named after A.N. Sysina» of the Ministry of Health and Social Development
Russian Federation
Russian Federation
V. I. Barsky
FSO, «Research Institute of Human Ecology and Environmental Hygiene named after A.N. Sysina» of the Ministry of Health and Social Development
Russian Federation
Russian Federation
I. K. Grazhdan
First Moscow State Medical University named after I.M. Sechenov
Russian Federation
Russian Federation
E. V. Cricova
The Scientific Center of Mental Health, RAMS
Russian Federation
Clinical Genetics laboratory
Russian Federation
Clinical Genetics laboratory
M. G. Aksenova
FSO, «Research Institute of Human Ecology and Environmental Hygiene named after A.N. Sysina» of the Ministry of Health and Social Development
Russian Federation
Russian Federation
S. G. Burd
Russian State Medical University named after N.I. Pirogov
Russian Federation
Department of Neurology and Neurosurgery
Russian Federation
Department of Neurology and Neurosurgery
E. I. Gusev
Russian State Medical University named after N.I. Pirogov
Russian Federation
Department of Neurology and Neurosurgery
Russian Federation
Department of Neurology and Neurosurgery
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Review
For citations:
Chukanova A.S., Tushkanov M.A., Barsky V.I., Grazhdan I.K., Cricova E.V., Aksenova M.G., Burd S.G., Gusev E.I. ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES. Epilepsy and paroxysmal conditions. 2011;3(2):45-54. (In Russ.)
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