ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES

A. S. Chukanova; M. A. Tushkanov; V. I. Barsky; I. K. Grazhdan; E. V. Cricova; M. G. Aksenova; S. G. Burd; E. I. Gusev

ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES

A. S. Chukanova, M. A. Tushkanov, V. I. Barsky, I. K. Grazhdan, E. V. Cricova, M. G. Aksenova, S. G. Burd, E. I. Gusev

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Abstract

We examined the clinical and genetic evaluation of SERT and TPH2 genes SNP polymorphisms role in the development of side effects during topiramate therapy taking into account gender features. Found significant differences in the severity of topiramate side effects in the nervous system and psycho-emotional sphere in patient groups with different variants of alleles, and identified gender features in elaboration of depression and emotional lability

Keywords

pharmacogenetics of epilepsy, topiramate side effects, SERT, TRN2

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For citations:

Chukanova A.S., Tushkanov M.A., Barsky V.I., Grazhdan I.K., Cricova E.V., Aksenova M.G., Burd S.G., Gusev E.I. ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES. Epilepsy and paroxysmal conditions. 2011;3(2):45-54. (In Russ.)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)

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Epilepsy and paroxysmal conditions

ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES

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Abstract

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Epilepsy and paroxysmal conditions

ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

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