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EPILEPSY IN CHILDREN WITH MYTOCHONDRIAL DISEASES: DIAGNOSTICS AND TREATMENT FEATURES

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Abstract

Mitochondrial diseases (MD) represent a large clinically heterogeneous group of disorders that arise as a result of dysfunction of the mitochondrial respiratory chain. The article discusses clinical features of the MD, accompanying by epilepsy. Two case reports are presented of MELAS syndrome and Alpers-Huttenlocher syndrome. The genetic background of MD is discussed as well as methods for establishing the diagnosis of MD and peculiarities of antiepileptic therapy

About the Authors

N. N. Zavadenko
GBOU VPO Russian National Investigational Medical University named after N.I. Pirogov, Ministry of Health and Social Development of the Russian Federation (Moscow)
Russian Federation


A. A. Kholin
GBOU VPO Russian National Investigational Medical University named after N.I. Pirogov, Ministry of Health and Social Development of the Russian Federation (Moscow)
Russian Federation


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For citation:


Zavadenko N.N., Kholin A.A. EPILEPSY IN CHILDREN WITH MYTOCHONDRIAL DISEASES: DIAGNOSTICS AND TREATMENT FEATURES. Epilepsia and paroxysmal conditions. 2012;4(2):21-27. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)