OUR EXPERIENCE IN APPLICATION OF AUTOLOGOUS BONE-MARROW-DERIVED MESENCHYMAL STEM CELLS FOR THERAPY OF PATIENTS WITH SYMPTOMATIC EPILEPSY
Abstract
Abstract: an article presented the data on application of autologous multipotent mesenchymal stem cells (MMSCs) from bone marrow for therapy of 10 patients suffering from drug-resistant symptomatic epilepsy. Intravenous injection of 40.0-101.0Ч106 (mean 68.2± 8,48Ч106) MMSCs endolumbal injection of 2.7-8.0Ч106 (mean 6.34±0.72Ч106) neuroinduced MMSCs did non induced in patients unfovarable reactions an complications. Moreover, during 3-11 months of monitoring 5 of 10 patients demonstrated decrease the frequency or disappearance of seizures, severity the incidence of seizures. 2 patients demonstrated increase of cognitive functions, 2 patients – decrease the level of anxiety. We concluded that application of MMSC-base cellular therapy id safe and enable to facilitate seizure status in patients with drug-resistant symptomatic epilepsy.
About the Authors
F. P. Hlebokazov
Republic Mental Health Research Center, Minsk
Belarus
Belarus
T. V. Dоkukina
Republic Mental Health Research Center, Minsk
Belarus
Belarus
S. I. Ighnatenko
Republic Transfusion and Medical Biotechnology Research Center, Minsk
Belarus
Belarus
S. M. Кosmacheva
Republic Transfusion and Medical Biotechnology Research Center, Minsk
Belarus
Belarus
N. V. Goncharova
Republic Transfusion and Medical Biotechnology Research Center, Minsk
Belarus
Belarus
M. P. Potapnev
Republic Transfusion and Medical Biotechnology Research Center, Minsk
Belarus
Belarus
M. V. Makhrov
Republic Mental Health Research Center, Minsk
Belarus
Belarus
P. P. Korolevich
Republic Mental Health Research Center, Minsk
Belarus
Belarus
N. N. Misyuk
Republic Mental Health Research Center, Minsk
Belarus
Belarus
I. V. Grigorieva
Republic Mental Health Research Center, Minsk
Belarus
Belarus
S. A. Marchuk
Republic Mental Health Research Center, Minsk
Belarus
Belarus
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Review
For citations:
Hlebokazov F.P., Dоkukina T.V., Ighnatenko S.I., Кosmacheva S.M., Goncharova N.V., Potapnev M.P., Makhrov M.V., Korolevich P.P., Misyuk N.N., Grigorieva I.V., Marchuk S.A. OUR EXPERIENCE IN APPLICATION OF AUTOLOGOUS BONE-MARROW-DERIVED MESENCHYMAL STEM CELLS FOR THERAPY OF PATIENTS WITH SYMPTOMATIC EPILEPSY. Epilepsy and paroxysmal conditions. 2014;6(1):6-14. (In Russ.)
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