Abstract: this paper presents the results of therapeutic drug monitoring of lamotrigine, an anticonvulsant epilepsy medication, in patients with cryptogenic focal epilepsy using plasma and saliva as a biological material for drug testing. Comparative analysis of the steady-state plasma and saliva lamotrigine concentrations (СssMIN and СssMAX) allows the conclusion that saliva can be used as a suitable biological substrate for therapeutic drug monitoring.

Abstract: the article presents the clinical observation of outpatients with a diagnosis of epilepsy in the children’s neurological department Morozovsky Children Hospital translation from the original on generic drug valproic acid. Such changes in anticonvulsant therapy in patients quarter led to a deterioration of the disease in the form of clinical remission failure, impairment at lectroencephalography, as well as the emergence of side effects from the gastrointestinal tract and deterioration of cognitive functions. On the basis of this observation can be confirmed by the fact that patients with epilepsyin remission is not recommended translated from the original drug to a generic.

Abstract: the purpose of this work was to improve the diagnostic methods of hormonal disorders in girls with epilepsy adolescence by examining indicators of thyroid, parathyroid glands, cortisol and identify their differences with the data corresponding to the level of hormones in the blood of a comparison group of girls. Material and methods. The study included 50 girls with epilepsy, aged from 8 to 17 years for girls and 47 comparison group of the same age. For all children, determined the blood levels of parathyroid hormone, triiodothyronine, thyroxine, thyrotropin, thyroglobulin antibodies and cortisol in accordance with instructions for use reagent for ELISA (Enzyme-linked immunosorbent assay) determination of hormones in human serum, approved by the Ministry of Health of the Russian Federation. The results of the study. Girls 8-17 years with epilepsy blood levels of parathyroid hormone, triiodothyronine, thyroxine, TSH and thyroglobulin antibodies were not significantly different. Significantly different blood levels of cortisol in girls 8-13 and 14-17. In girls, the comparison group blood levels of parathyroid hormone triiodothyronine and significantly different for children 8-13 and 14-17 years, for thyroxine – children 8-9 and 10-17 years, for cortisol – children 8-11 and 12-17 years. The blood levels of a comparison group of girls 8-17 years of TSH (thyroid stimulating hormone) and thyroglobulin antibodies were not significantly different. Cortisol levels in the blood of girls with epilepsy younger and older age groups was significantly higher than that of the comparison group of girls in these age groups, the level of parathyroid hormone T3 and – significantly higher than that of girls 14-17 years of comparison, the level of thyroid stimulating hormone, antibodies to thyroglobulin and T4 – significantly higher than the comparison group of girls aged 8-17. Conclusions. Revealed changes in hormone levels in the blood of girls with epilepsy compared with a comparison group based on age and investigated their reliability.

Abstract: the current concept of the structural and functional organization of the blood-brain barrier (BBB) was discussed in part one of the literature review. In the second part, we describe the development of the BBB concept. Beginning from the twentieth of the last century, the process of accumulation of knowledge about BBB is characterized by progressive increase of fundamental and applied studies on the subject. In order to better understand the role of BBB we must consider its ontogenetic development. Experimental studies addressed this issue by way of verifying the presence of neurospecific antigens to show a gradual formation of the BBB structures when the completion of their formation not always coincide with the time of organism birth. These observations are very important for determination of the role of the BBB “breakthrough” in the occurrence of epilepsy, infantile cerebral paralysis (ICP) and other long-term neurological disorders which can be associated with perinatal hypoxic-ischemic brain injury. Understanding of the ontogeny of the BBB is also important in defining the modern diagnostic and treatment approaches including immunochemical verification of eurospecific proteins (NSP) in biological fluids and neuroprotective therapy.

Abstract: rolandic Epilepsy is one of the most common forms of idiopathic epilepsy. Its clinical profile and intercritical EEG are well-defined and widely described in medical literature. However, ictal EEG patterns in benign focal epilepsy with centrotemporal spikes are rarely recorded due to low frequency of seizures, mostly occurring during sleep. Only a small number of publications on the subject are available globally. This article provides a description of an ictal EEG during a roladic epileptic seizure.