The purpose of work was to study polymorphism of kinematic variants of secondary generalized convulsive seizures by research of lesional and non-lesional mesial temporal epilepsy. For this purpose the patients suffering by non-lesional variants of mesial temporal epilepsy were analyzed: patients with epilepsy against chronic abusing alcohol (100 patients), patients with epilepsy against a chronic ischemia of a brain (62 patients) and patients with lesional mesial temporal epilepsy (with mesial temporal sclerosis, 31 patient). In a group with non-lesional mesial temporal epilepsy the main type of seizures were secondary generalized convulsive seizures with fast clinical generalization (91,4 %). In a group with lesional mesial temporal epilepsy the main type of seizures were secondary generalized convulsive seizures with slow clinical generalization (90,3 %). In addition discovered various clinic-encephalographic variants of generalization secondary generalized convulsive seizures: with slow clinical and slow encephalographic, slow clinical and fast encephalographic, with fast clinical and fast encephalographic, fast clinical and slow encephalographic generalization.

This paper presents experience of using Vimpat in outpatient health care chain of Moscow. In the observational study were attended 49 patients with difficult for treatment focal forms of epilepsy (cryptogenic and symptomatic forms). Vimpat used in complex therapy in the mean effective dose of 300-400 mg per day. As a result, the data on a cohort of Russian patients showed that Vimpat demonstrate a sufficiently high clinical efficacy (55%, p<0.01) and appropriate for use in patients with difficult for treatment forms of epilepsy in complex therapy when the previous treatment was ineffective.

According to epidemiological studies, in developed countries from 1 to 2% of the population suffering from headache associated with the abuse of analgesics. The lack of a structured understanding of the abuse headache pathogenesis, the difficulty of well-timed diagnostics and choice of effective treatment resulting of the relapse in 30-50% within 1-5 years. The aim of the study was to investigate the clinical and psycho-physiological characteristics of abuse headache and during the period of withdrawal abuse medication with "detoxification" therapy. According to the study, most patients with abuse headache abused combined analgesics (88%). We are observed a statistically-valid higher level of drug dependence, reactive and personal anxiety, depression and sleep disorders in patients with abuse headache. Development of drug withdrawal period was different in the groups with migraine and tension-type headache (lower intensity of headache was observed in the group with migraines), as well as in groups with one-stage and gradual drug withdrawal (headache course with one-stage withdrawal clinically was more easily). Increase in the overall amplitude response N75/P100, with an emphasis in the period of drug withdrawal and lack of habituation N75/P100 in patients with AGB were detected. This may indicate the increase in cortical excitability due to reducing the inhibitory thalamo-cortical and intracortical influences. Analysis of the results proves the effectiveness of the usage «detoxification» therapy in the acute phase of abuse drug withdrawal, and gives reason to recommend it to practical use in conjunction with the prescription of preventive treatment.

We are study the onset age of epilepsy in a cohort of 155 women of reproductive age and the effect of onset age on the severity of epilepsy and the occurrence of reproductive disorders. The prevalence of epilepsy debut in adolescence with maximum rate in menarche and ovulatory cycles from 12 to 16 years old was identified. We are demonstrated that debut of epilepsy in adolescence hasn't influence in the future on the frequency of attacks and the occurrence of reproductive disorders in epileptic patient.

The structure of idiopathic focal epilepsy was studied with 1118 patients who have diagnosis «epilepsy» with debut of seizures at the age from first days of life to 18 years. The methods included clinical examination, video-EEG monitoring, neuropsychological testing and neurovisualization methods if necessary. Idiopathic forms of focal epilepsy were observed in 189 cases, which rated 16.9% of the total group of patients with debut of seizures. A diagnosis of «idiopathic focal epilepsy (IFE) with central temporal spikes» was arrived in 99 cases (8.8% of patients). Idiopathic occipital epilepsy (IOE) was detected in 47 patients (4.2% of cases). IFE with pseudo generalized attacks (IFE-PGA) - 31 patients (2.8% of cases). Idiopathic focal epilepsy of infancy (IFEI) was observed in 5 cases, which rated 0.5% of the total patients group. Idiopathic focal epilepsy with affective symptoms (IFEAS) was observed in 7 patients (0.6%). In IFE most often detected rolandic epilepsy (in 52.4% of cases). Idiopathic occipital epilepsy was diagnosed in 24.9% of cases. IFE-PGA was observed in 16.4% of patients, IFEAS - in 3.7% of cases and IFEI - in 2.6%. Overall, the results correspond to data obtained in the majority of foreign studies the incidence of idiopathic local forms of epilepsy.

West's Syndrome prognosis is extremely complicate due to the large number of potential prognostic factors. This review contains the factors affecting the termination of epileptic spasms and conducive to the maintenance of remission. These factors were: idiopathic and cryptogenic etiology, the later debut of the disease, the absence of asymmetric spasms and focal seizures, the absence of an asymmetric pattern and synchronization of the EEG, early start of therapy, the correct choice of drug and the normal development before going to the doctor, as well as the implementation by parents of patients prescribed recommendation, the occurrence of side effects, the concomitant diseases, the different form of state disease, the availability of antiepileptic drugs and surgical treatment.