The author dedicated the article to the outstanding scientific achievements of his mentors, who represented the Moscow Neurological School founded by Dr. E.K. Sepp and Dr. M.B. Zucker, and accompanied his story with invaluable personal memories about their everyday scientific and clinical practice and personal human qualities. It also demonstrated how the fundamental concepts put forward by Dr. E.K. Sepp were developed and expanded by his students by using modern research methods.

This report has been dedicated to study facial neurology, which were profoundly impacted by Professor V.A. Karlov. Dento-neurology as a separate medical field assessing diagnostics and treatment of face and neck pain syndrome, therapy of cerebral-cranial nerves and defuncted maxillotemporal joint. Importance of visualization techniques used upon therapy of trigeminal neuralgy was emphasized.

The report substantiates the concept of combining the Kozhevnikov Neurological School with the Moscow School of Neurology. It is shown that almost all the great Russian neurologists passed through the clinic created by A.Ya. Kozhevnikov. The representative of this school, V.A. Karlov, consistently follows the principles laid down by the teachers, that allows him to create new concepts of neurology and develop the Moscow Neurological School.

Multiple aspects covering multiannual close cooperation between Dr. V.A. Karlov and prominent scientists from the Research Center of Neurology have been illuminated in the report. It was shown how an extended study was performed at the joint between two medical disciplines and what importance for the staff had Professor Karlov pedagogical activity.

The report presents the main areas of work of the Chair of Nervous Diseases (Faculty of Therapy, Yevdokimov Moscow State University of Medicine and Dentistry). The rich experience of clinical and instrumental diagnostics obtained by the staff of the department for half a century of its existence is shown. Special attention is paid to the role of thermal imaging and ultrasound in the early diagnosis of various vascular pathologies.

A multi-year career path and overwhelmingly rich legacy of Professor V.A. Karlov are presented in the report. Prominent publications related to the main research directions of his work as an outstanding scientist and clinician are outlined.

The report is dedicated to the landmark work by V.A. Karlov “Epilepsy in children and adult women and men”, 2nd edition, released in 2019. Here, there are discussed crucial aspects underlying a theory and application for epilepsy treatment reflected in the monograph that underline a great importance for complete all-encompassing analysis of experience and advances in domestic and foreign epileptology described in the book.

Here are reported the data of investigating clinical evolution of perinatal brain pathology performed under the auspices of Professor V.A. Karlov. Analysis of the data obtained revealed an importance for detecting ante- and intranatal predictors for most relevant neurological disorders in childhood: neonatal seizures, some epilepsy forms, headache and attention deficit / hyperactivity disorders. The speaker argues for the necessity to conduct topical diagnostics of the nervous system disturbances in neonates and justifies a relationship between early and delayed neurological disorders in diverse pediatric periods.

The report shows that V.A. Karlov proved at the current level of knowledge the correctness of the ideas of the great English neurologist John Hughlings Jackson, author of works on localization of the projection motor centers of the cerebral cortex, on aphasia, and others.

The report considers an important issues of the course and treatment of epilepsy in women. Specific aspects of the problem are noted, the basic principles and features of the treatment of female epilepsy are shown, the problems of pregnancy planning are discussed.

The report presents the current principles of treatment of various types of epileptic seizures and forms of epilepsy. High efficacy and good tolerability in mono- and combination therapy with lamotrigine are shown, including its beneficial effects on cognitive function, behavior, and mood in children.

The report presents data on the evaluation of efficacy and tolerability, as well as the dynamics of epileptiform activity index in adolescents and adults with newly diagnosed focal epilepsy during lacosamide therapy.

The results of successful treatment of schizophrenic psychosis with persistent catatonic symptoms, refusal to eat in a patient with epilepsy are presented. In view of the progressive course of the disease, the lack of dynamics from the ongoing drug treatment, the method of electroconvulsive therapy was applied. Epileptic seizures and visual signs of brain epileptization were absent with the development of psychosis. As a result of the course of electroconvulsive therapy (9 procedures), the patient's clinical condition improved significantly. This observation illustrates the possibility of using electroconvulsive therapy in combination with antipsychotics and antiepileptic drugs as an alternative method for treating drug-resistant epilepsy.

Closing the conference, Professor V.A. Karlov, President of the Russian League Against Epilepsy (RLAE), shows how to use it’s potential to solve the most important tasks set for the present domestic medicine. He touches upon the problems of health care financing, treatment of epilepsy “through life”, interdisciplinary interaction of epileptologists with obstetricians and gynecologists, neurologists, psychiatrists, neurosurgeons, as well as the state of the epileptological service in the Russian Federation as a whole.