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Epilepsia and paroxysmal conditions

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Vol 3, No 4 (2011)

DISTINCTIVE ARTICLES

8-13 255
Abstract
Kabuki syndrome is rare genetic disorder. Patients with this syndrome are phenotypically similar to Kabuki actors. The authors present a review article which describes the history, etiology, clinical features, diagnosis, and approaches to therapy of this syndrome. Special attention is description of a clinical case of Kabuki syndrome. Particularities of epilepsy clinical course, EEG patterns and treatment of girl with this syndrome were examined
14-21 122
Abstract
Derealization is mental disorder, manifested in a feeling of unreality and strangeness of the surrounding real world, a form of impairment of consciousness. The most common and recognizable such disorder is the phenomenon of «déjà vu» – deja vu (DV). Objective: to study the clinical and diagnostic value derealization disorders (DD) in epilepsy. Materials and Methods: the total study group was 152 persons (mean age 25,17±9,19; 63,2% of women). The phenomena of derealization were compared in groups of healthy subjects (n = 139) and patients with epilepsy (n = 23). Patients were interviewed on the DV characteristics and long-term (12-16 hours) ambulatory EEG monitoring was conducted. Results: the same frequency of DV in patients with cryptogenic and symptomatic focal epilepsy was demonstrated. DV could be combined with any types of seizures, it could be aura of a seizure or own seizure. The main clinical characteristics that differentiate DV in healthy from DV in patients with epilepsy are: frequency, fear of the onset DV and emotional coloring. The most important criterion is the dynamic characteristics of the DV: elongation increased the appearance of negative emotions. The DV phenomenon characterized in EEG by start with polyspiking activity in the right temporal leads and, in some cases, ended by slow wave, theta-delta activity in the right hemisphere
22-27 121
Abstract
The pineal gland hormone melatonin is the main regulator of biological rhythms. It affects sleep, brain bioelectric activity and seizures. The majority of experimental and clinical studies are confirmed the anticonvulsant properties of melatonin. However, in the scientific literature there is no data on the concentration of melatonin in adult patients with epilepsy and epileptic syndromes. Thus study of melatonin in adult patients was developed. The evening (1 hour before bedtime), night concentrations (morning), and excretion of melatonin in 54 patients with focal symptomatic epilepsy at the age of 21 to 47 years were evaluated. It was found that seizures provoke a decrease of melatonin concentration.
28-34 99
Abstract
With the aim being evaluation of psychological functioning in children while benign epileptiform discharges of childhood are being formed (BEDC) (in the EEG results) a group of 13 children with organic brain lesions - neuroimaging verified and neuroimaging non-verified -has been formed. All of the patients were diagnosed with various focal epilepsies and showed different levels of cognitive deficits. All of the patients underwent electroencephalograph assessment with at least once-a-month frequency. Patients with verified diagnosis of benign epilepsy of childhood with central-temporal spikes were not included into the study. Upon EEG dynamic assessment administration all the children included in the study showed (which was no longer present at the time of control assessment in 1-2-3 months) transitory complexes in the form of benign epileptifom discharges of childhood (BEDC) which in its turn coincided with a clinical improvement of cognitive aspects in all children (attention, hyperactivity, speech) regardless of whether they had any brain organic lesion or not and severity thereof.

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)