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Epilepsia and paroxysmal conditions

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Vol 4, No 3 (2012)

DISTINCTIVE ARTICLES

6-13 131
Abstract
Fotoparoxismal reaction (FPR) on the EEG is often on receiving child neurologist, epileptologist. It is registered as patients with epilepsy (not just fotosensitivety) and in patients without epileptic seizures. The results of observations of two groups of children with fotoparoxismal reaction in the EEG: 44 children with no history of epileptic seizures and 116 – with various forms of epilepsy. Children with IDF without this type of epileptic seizures abnormal activity in the EEG was most often monosymptomatic or combined with spontaneous generalized epileptiform activity in the background and during hyperventilation. Children diagnosed with epilepsy and a third of the IDF had a combination of different attacks, dominated by generalized tonic-clonic, myoclonic, and complex partial absense. Should be video-EEG monitoring of sleep day or night to the additional tests to rule out “subclinical” seizures in children with known IDF on a routine EEG. Children without epileptic seizures with the IDF is not recommended antiepileptic therapy before the appearance of epileptic seizures.
14-18 91
Abstract
For the first time at children of five various nationalities living in the territory of the Astrakhan region, polymorphism of a gene of CYP2C19 on a polymorphic marker of G681A is studied. Statistically authentic distinction in frequencies of occurrence of genotypes of CYP2C19 associated both with fast, and with a slow metabolism of medicinal means substrata that testifies to importance of individual studying of polymorphism of CYP2C19 is revealed. It is studied, on restored glutathione blood, activity of the second phase of biotransformation of anti-epileptic preparations. Offers on improvement of pharmacotherapy of epilepsy at children are created.
19-28 564
Abstract
Influence of Pregabalin on brain KT-perfusion condition at 28 patients (21 men and 7 women) at the age from 17 till 35 years (middle age 27±8,18 years) with various forms of symptomatic epilepsy during the period 2008-2011gg is studied. All patients applied various antiepileptic means. Frequency of EP from 5-17 (±11,4) in a month. Prior to the beginning of application Pregabalin to all patients KT-perfuse of a brain is made. On a brain KT series before intravenous introduction of 50 ml Omnipac 300 and at KT-perfusion research at 87 % of patients in temporal shares and in cortical departments, near Sylvie’s crack are revealed the hipoperfusion centers with decrease in indicators of CBV, CBF and strengthening peak to level of values of white substance of a brain. Asymmetries of values on other parametrical cards in the field in comparison with a counterlateral hemisphere aren’t defined. These data coincided with results of EEG. Probably at patients with epilepsy chronic ischemia of certain structures of a brain, especially against absence of effect from PEP carried out before therapy that leads to chronical ischemia of a brain is formed. In 30-60 days, after addition to used PEP Pregabalin EP reduction at 61,7 % of patients for 78 % and the termination – 38,9 % is noted. Positive dynamics in the form of improvement and perfusion normalization in temporal shares and cortical departments, near Sylvie’s crack in 77 % is revealed. These data coincided with results of EEG. At repeated KT perfusion in 12 months these results remained. Patients who independently stopped reception Pregabalin recurrence of EP and a former picture of a hipoperfusionis noted. Application of Pregabalin promoted reduction of quantity of attacks at patients with various forms of symptomatic epilepsy that led to improvement of a perfusion of a brain
29-33 100
Abstract
This article provides a detailed description of clinical presentations of different types of somatosensory auras, that is, the different types of numbness or paresthesia sensations, as well as of rarely seen somatosensory delusional perceptions. The objective of this article is to provide a detailed clinico-electroencephalographic and neurovisual analysis of a group of patients experiencing somatosensory auras. Test group included 15 patients (М-11, F-4, average age – 13 ± 8 years) with etiologically different forms of partial epilepsy, i.e., the idiopathic, symptomatic or cryptogenic epilepsy. It was established that in these patients the interictal epileptic pathological EEG activity was significantly more often registered in the central temporal or parietal lobe but significantly less frequently in the temporal lobe in its own right. In 47% of cases changes on MRT correlated with clinical presentations of epilepsy and pathological changes on EEG. The authors compare the results obtained with previously published ones. The article contains conclusions and recommendations that are helpful in daily medical practice.
34-40 74
Abstract
Studied efficiency of application Sazar (lamotrigin, Alcaloid, Macedonia) in polytherapy at sick of an epilepsy with partial and generalized tonic-clonic convulsive attacks, and also dynamics of disturbing frustration with application of a scale of alarm of Hamilton (HARS) and activity of vegetative nervous system on an index of Kerdo. 214 patients at the age from 15 to 71 years are treated. Used doses of a preparation from 150 mg to 450 mg per day. Research has shown that preparation action comparably on anti-spasm to effect with action lamotrigin. In groups of patients with cryptogenic and a symptomatic epilepsy reduction of quantity of attacks more than on 50% through 12 months after Sazar addition, and in group with an idiopathic epilepsy reduction of attacks more than on 90% per month were noted. The influence spectrum on symptoms of alarm and an index of Kerdo has appeared uniform throughout all period of supervision from 8 to 22 months.
41-47 69
Abstract
The article contents the quality of life analysis by QOLIE-31 in epilepsy patients which has been treated with repetitive transcranial magnetic stimulation (rTMS). Combination of rTMS and low AEP doses allow controlling epilepsy progress and ensuring satisfactory anticonvulsive result. Data of research permit to reasonable addition of rTMS to epilepsy treatment for optimal result for each patient with minimal side effects and with quality of life improvement.
48-49 64
Abstract
This article presents the results of vagus nerve chronic stimulation in 11 patients with pharmacoresistant epilepsy who are not on the wait-list for direct surgical treatment. During the first three months of nervestimulation 27,3% of patients demonstrated a 50% seizure-frequency reduction as compared to baseline, with no surgical or infectious complications. 27,3% Of patients demonstrated transient side effects of nerve stimulation, such as dysphonia, trouble breathing or throat paresthesias.

THESIS



ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)